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Levothyroxine, Fosamax and problems with liver blood work

I'm new to this site. I was diagnosed hypothyroid eight months ago. At the time I didn't really have a lot of symptoms - before that, my doctor was investigating why my cholesterol level was so high, as my diet/weight etc are all pretty good.  I  spent  six months trying to bring the cholesterol into the normal range - and succeeded  (although it's still on the high side - the doc was happy) just by cutting down on dairy foods.
When my TSH level was discovered to be 5.83 (I live in France so the levels may be different - normal range is from 0.18 - 3.00) I was then referred to an endocrinologist.
After eight months taking Levothyroxine 50ug and Fosamax - without any real problems - I have now discovered that although my TSH level has reduced (2.45)  my Gamma levels (liver) have gone through the ceiling (Gamma G.T. before  the medication was 19UI/l - normal range is from 0 - 36. now it's 183 UI/l.
Has anybody else had any problems with liver blood work after taking this medication?
9 Responses
1299122 tn?1281044016
Here is an article about alendronate therapy (bisphosphonates) and elevated liver enzymes.
Avatar universal
I am unsure of the effects of thyroid meds on the liver, but I do know that Statin Drugs to treat High Cholesterol do affect the Liver Enzymes and raise them in many people, High Cholesterol is known to be caused by thyroid disease, along with high blood pressure. Alcohol has the same effect on liver enzymes as the statin drugs, The first time I had a Lipid panel done after being prescribed Lipitor , the MD's nurse asked me if I was aheavy drinker? I said no, I don't consider myself a drinker at all. But it was the statin drugs that caused it, Is the gamma level you mentioned considered a liver enzyme or is that a different lab?  Good Luck FTB4
649848 tn?1534637300
There are no known allergies to levothyroxine, as it is identical to the T4 produced in your body.  I would, however, suspect the Fosamax.  Can you try a different medication for osteoporosis?  I rebuilt my bone by supplementing with calcium, magnesium and vitamin D.

High cholesterol is often caused by hypothyroidism, and once thyroid levels are normalized (for you), cholesterol levels often come down.
Avatar universal
Thanks very much for the replies. The further information below maybe of use - even though they are French definitions - the normal range should give a clue!
Triglyceride  1.28g/l  (normal range 0.40 - 1.70)

T.G.O. (ASAT)  33mUI/ml  (normal 0 - 34)
T.G.P. (ALAT)   41mUI/ml (normal 0 - 55)
GAMMA G.T.   183UI/l (normal 0 - 36)
As for the Fosamax - in addition I'm already taking a calcium booster with Vit D  - also magnesium. I intend to use the fosamax only for a couple of years at the most, as I am very suspicious of it's longer term use.
1299122 tn?1281044016
I'm glad that you have decided to use Fosamax for only a couple years. I'd also like to suggest the website "Save Our Bones" which endorses a more natural approach to strengthening bones instead of using bisphosphonates. (Boniva, Fosamax, Actonel etc)
One of the reasons we lose mineral density in our bones is because of the highly acidic diets we consume. Our body tried to maintain a proper ph level and leeches the calcium out of our bones to try to keep our cells from becoming too acidic.
I hope you will google "bisphosphonates" and research whether you really need this drug. It does not build bone, rather is interferes with "resorption" - however, if you go to the site I recommended you will find out a great deal.
Avatar universal
Thanks Shelley for that info. Problem is I'm always wary of the  'hard sell' - and Save Our Bones is certainly that.
I agree with your opinions on bisphosphonates - I've trawled the internet also, trying to find some natural solution to building up bone density - to not much success.
Currently at my endo's request I've eliminated alcohol for 3 weeks  - to see if the Gamma G.T. returns to normal - I'm sure it won't, as my alcohol consumption has not changed over recent years.
I'm really hoping it's connected to either the  Levothyroxine  and/or the Fosamax - as my blood works were fine before I started this medication 8 months ago.
I'm hoping she'll agree that I should stop taking the Fosamax for a least a period of time to get it out of my system before having more blood work done.
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649848 tn?1534637300
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1756321 tn?1547098925
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