Excerpt from the book "Differential Diagnosis by Laboratory Medicine: A Quick Reference for Physicians" edited by Vincent Marks, Dusan Mesko...
Thyroglobulin is quite a strong autoantigen. In healthy blood there are many B-lymphocytes with membrane-bounded IgM type thyroglobulin antibodies. IgG antibodies against thyroglobulin are Hashimoto's thyroiditis markers. The presence of autoantibodies to thyroglobulin can lead to the functional destruction of the thyroid gland.
Test Purpose. To detect and confirm autoimmune thyroiditis, Hashimoto's thyroiditis.
Increased Values - positive. anaemia (pernicious a., autoimmune hemolytic a.), rheumatoid arthritis, autoimmune disorders, granulomatosis, hyperthyroidism, hypothyroidism, systemic lupus erythematosus, Graves' disease, myasthenia gravis, idiopathic myxedema, myxedema coma, myxedema heart disease, thyroid tumours, syndrome - (Down sy, Sjogren's sy, Turner's sy), thyroiditis - (Hashimoto's t., de Quervain's subacute t.), thyrotoxicosis, rheumatoid - collagen disease, non-toxic nodular goiter
Interfering Factors: healthy people, medicaments - (amiodarone)."