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Thyroid Disorders Community
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Avatar universal

Possible thyroid issues...need advice.

Ok, I'm new to this so here it goes.  I am 34 years old, 5' 7" and 145 pounds. Approximately 4 years ago I did treatment for Hep C (which is now completely gone).  After completing treatment I had extreme exhaustion which my pcp contributed to the 6 months of treatment with interferon A and other meds.  Approximately 3 years ago my pcp finally took my complaints about exhaustion seriously and did blood work everything came back "normal" except that my thyroglobulin AB levels were high.  Of course nothing was done about this as all my other labs were "normal".  4 years later and I am still exhausted all the time, my thyroglobulin ab has doubled and my "complaints" seems to be getting worse.  Now I have other "complaints" like random sweating (to the point that my clothes are wet), cold sensitivity, coarse fragile hair, loss of libido, mood swings and of course exhaustion to the point that I can't even concentrate.  Oh did I mention my memory *****!  I have finally convinced my new pcp (we moved) to do new blood work as I have an appointment with an endocrinologist next week.  The results are as follows:

T3 Free 3.1 (normal range 2.0-4.8)
T4 Free 1.2 (normal range 0.8-1.7)
TSH 2.81 (normal range0.45-4.50)
Thyroglobulin <1 (normal range <56)
and Thyroglobulin AB 109 (high) (normal range <41)

My pcp says I am wasting my time and money going to the endocrinologist.  She says my labs are normal thus there is nothing that can be treated.  Is she right am I wasting my time and money?  Has anyone else had symptoms with normal labs?  Am I just going to feel awful forever?
17 Responses
Avatar universal
No one cares about ur health more than you, sure doctors are educated but sometimes they are so used to routine and standards they forget about exceptions and new findindings. I had head aches n was told to just take medication .... I made them aprove for an MRI long n behold had a brain tumor .... I did research on line n identified my symptoms w cancerous tummors ..... Dr refused to do surgery I was only 20 y/o at the time. Within 7 days I lost my ability to walk, talk, and basically function ... Dr was sure that surgery would not benefit me n my symptoms must be something else.... again advocating for my self w support of family Dr agreed to do brain surgery n it was cancer.  Tumor doubled in size within the 7 days I would have died within the next week had he not done the surgery. Long story short money n time is worthless if we don't have our health to enjoy them. Only u know what ur feeling n I wouldn't stop until u get atleast an explanation for ur symptoms
Avatar universal
I wish you luck finding someone to help you.  Perhaps try a naturopath.  You can do a search online for docs in your area.  look at www.thyroid-info.com.  There's so much more involved in diagnosing and treating thyroid disorders.  Not too many docs out there will listen.  They prescribe anti-depressants because they think we're nuts.  You really have to be your own advocate.  I'm tried numerous docs without success.  I have an appointment with a naturopath soon, hope she will agree to help me.  I hope letting this go for 12 years hasn't been a mistake.  I've had 8+ nodules .5cm to 2cm each and they are causing me issues.  Guess it's not a big deal and doesn't warrant their time though. Very frustrating.
1756321 tn?1547098925
"In an article authored by Alan R. Gaby, M.D. (B.A. from Yale University, M.S. in biochemistry from Emory University, and his M.D. from the University of Maryland.) that is titled “Autoimmune thyroiditis as a cause of chronic fatigue”, he details a medical research study involving 219 patients with Chronic Fatigue Syndrome (CFS), having severe fatigue of at least 1-year in duration. While only half of the patients were found positive for either antithyroidperoxidase antibodies (Anti-TPO) or antithyroglobulin antibodies (Anti-TG), 40% were found to have definite histological evidence of Hashimoto’s thyroiditis.

Hypothyroidism Elusive to TSH Testing

The study-patients in the research cited by Dr. Gaby MD, had varied TSH readings upon being blood tested (pituitary hormone that reflects thyroid hormone levels) with many falling within normal lab values. The study points out that possibly up to 40% of CFS patients are experiencing thyroid disease that will be responsive to thyroid hormone replacement therapy and that hypothyroidism causing symptoms, can be present despite normal TSH levels. It also points out that FNA may be required to detect autoimmune thyroiditis in a significant number of cases."

To read more: Thyroid Disease and Chronic Fatigue Syndrome: Misdiagnosis and Co-morbid Diagnosis | Suite101.com

***

"If you suspect low thyroid function, but have had "normal" blood tests, you and your doctor may want to take a second look. A TSH of greater than 2.5 is not normal. (For an appointment with our Naturopathic Doctor, click here.)

Ten years ago, the American National Academy of Clinical Biochemistry narrowed the reference range for thyroid stimulating hormone (TSH) from 0.5-5.0 to 0.2-2.5mIU/L.  Similar revisions by the American Association of Clinical Endocrinologists (AACE) meant that 13 million people previously considered to be normal, could now become officially diagnosed with under-active thyroid.  (1)

You should also consider the fact that TSH is lower if the blood test is taken later in the day, and if you ate before the test. (2) Other factors can cause an inaccurate TSH reading, such as a deficiency in the adrenal hormone cortisol.

The most important test for thyroid is the blood test for thyroid antibodies. Thyroid antibodies can cause symptoms even when TSH is normal. In particular, they have been shown to have a role in fertility and miscarriage. (3,4)

Thyroid antibodies cause symptoms even when thyroid reading is normal
"...it raises the possibility that optimal doses of thyroid hormone will not completely ameliorate all symptoms" - Dr Emerson (editor of journal Thyroid)

New research has shown that Hashimoto's patients with high thyroid antibodies report more symptoms than patients with low thyroid antibodies, even if their thyroid function test is normal. In other words, thyroid replacement is not enough to ameliorate symptoms of autoimmune thyroid disease. (5)

Untreated thyroid disease leads to heart disease, muscle weakness, poor mental function, and an increased risk for cancer. Some experts believe that it may be responsible for 40% of unexplained cases of fatigue, depression, weight gain and infertility (6)."

To read more: Sensible Alternative Hormone Clinic - Thyroid disease.
Avatar universal
While your FT3, FT4 and TSH look pretty good, there is one test in there that is not "normal", the TGab.  It's elevated, which probably indicates Hashi's.  That should be confirmed with TPOab (thyroid peroxidase antibodies).

I don't think you're wasting your time seeing an endo, depending on the endo, of course.  With your elevated TGab, TPOab should be run to confirm Hashi's, unless the endo is prepared to diagnose Hashi's without it.

However, it might be hard to get a doctor to put you on meds because your FT3, FT4 and TSH are within normal limits.  Some believe Hashi's doesn't need to be treated until lab values go out of range.  Others think it's best to treat early and avoid sinking into hypo hell.  You will most likely have to find a doctor of the second philosophy and one who treats clinically (by relief of symptoms).  All endos are not created equal...some only want to treat diabetes and are really not good thyroid doctors.

As far as "normal" labs are concerned:  We all have a comfort zone within the population range.  While I might be comfortable low in the ranges, you might have to be way up in the top for symptoms to be relieved.  We will not all be symptom-free just because we are somewhere in the range.

Let us know what your new endo has to say, and maybe we can help you to sort out how good a thyroid doctor he is and what your next move might be if he doesn't think you need to be treated.
Avatar universal
I'd add that with all your symptoms and test results showing Hashi's, your Free T3 is too low in the range.  Although as goolarra said,, some patients get by with free T3 low in the range. the range is too broad, and many patients do better with higher Free T3.  I won't get into the reasons for the ranges being too broad right now, but suffice to say that normally healthy people without hypo symptoms typically fall into the upper half of the range.  This is what I call the functional range.  Just to be average within the functional range your Free T3 would need to be about 4.1.  

Your doctor is wrong in saying there is nothing that can be treated.  A good thyroid doctor will treat a hypo patient clinically by testing and adjusting Free T3 and Free T4 as necessary to relieve symptoms, without being constrained by resultant TSH levels.  You can read about clinical treatment in this letter written by a good thyroid doctor for patients that he sometimes consults with from a distance.  The letter is then sent to the participating PCP of the patient to help guide treatment.  

http://hormonerestoration.com/files/ThyroidPMD.pdf

In the letter, please note these statements.  "the ultimate criterion for dose adjustment must always be the clinical response of the patient. .............. the well- replaced patient’s FT4 will be below the middle of its range, and the FT3 will be high “normal” or slightly high before the next AM dose."

Just because you will be seeing an Endo does not mean he will be a good thyroid doctor.  Many of them specialize in diabetes, not thyroid.  Also, many have the "Immaculate TSH Belief" and only use TSH to diagnose and treat a thyroid patient.  That doesn't work.  Others will test beyond TSH, but then use "Reference Range Endocrinology" and insist that a test that falls within the reference range is adequate for you. That also doesn't work.  

So when you see the Endo you need to find our if he will treat clinically, as described above and in the letter, and also if he will prescribe T3 meds if needed.  If either answer is no then I don't have much hope for that doctor treating you adequately to relieve your symptoms.  

Should that be the case, if you will tell us your location perhaps a member can recommend a good thyroid doctor for you.  

Also, if you haven't been tested for Vitamin A, D, B12, ferritin and a full iron test panel, you should request those as well..  



Avatar universal
Thank you for your advise!  I hope you are well.
Avatar universal
Red-Star,  Thank you for your information.  I am definately going to review the links you provided.  
Avatar universal
gimel,  Thank you for your help! I know that I have low vitamin D and calcium.  My pcp told me to start taking bothof these roughly two years ago.  I have not had them tested since.  I will ask the Endo about this.  Additionally, I live in GIlbert, Arizona.  Any referrals for Endos would be greatly appreciated.  I will keep you all posted after my appointment on Tuesday.

Thanks again!
649848 tn?1534637300
COMMUNITY LEADER
Specifically, get vitamin B12 tested.  Deficiency can cause the most debilitating fatigue/exhaustion.  I have to keep my B12 level at the top of the range, in order to feel well.
Avatar universal
Ok, just got back from the Endo.  He is running some more blood tests to check vitamin D again and then is sending me to the hospital for testing on my adrenal function (can anyone explain this to me).  If my adrenal function comes back normal he will then start me on levothyroxine at a low dose.  He states he would like to see my TSH go down from 2.81 to 1.  any suggestions or comments are greatly appreciated!  And, thank you again to everyone for giving me great advise.  I truely appreciate your support.
1756321 tn?1547098925
The use of thyroid hormones is contraindicated (reason to withhold treatment) in patients with uncorrected adrenal insufficiency.  I knew about this warning but needed to start thyroxine ASAP. I had a bad case of adrenal insufficiency so i was ready for some unpleasant symptoms. I just didn't know they would hit overnight!

After i started my first thyroxine tablet (at 2am - insomnia drama lol) i woke up the next afternoon and could barely move or speak. It felt like i had weights on my arms and legs. I was able to slur out a few words at best.  It was like i had been heavily drugged.  When i could finally get out of bed, i was hit with severe dizziness that afternoon which lasted quite some time.  I slept this comatose/drugged sleep for 15 hours a day for about a month. My body numbness worsened (may be adrenal related but not 100% due to affected central nervous system issues). A good contraindication to take note of. :)


Avatar universal
when your doctor says that he would like to see your TSH around 1, that sent off alarm bells for me.  TSH is totally inadequate as a diagnostic for thyroid even when not taking thyroid meds.  When taking thyroid meds, it is practically useless.  That is why I gave you the link above, and this quote.

"the ultimate criterion for dose adjustment must always be the clinical response of the patient. .............. the well- replaced patient’s FT4 will be below the middle of its range, and the FT3 will be high “normal” or slightly high before the next AM dose."

If your doctor does not want to treat you clinically, instead of using TSH, I think you need to find a new doctor.
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649848 tn?1534637300
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1756321 tn?1547098925
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