TPO over 900 but all other Thyroid normal

[jbjb5]

Just had a thyroid test and all other thyroid numbers are normal, but TPO is over 900.  I also have an atrophic kidney due to renal artery stenosis resulting in uncontrollable blood pressure.  I sleep solidly many days 20 hours & am exhausted always.  My legs and arms have no strength.  Can these symptoms be from the high TPO and is a high TPO indicative of anything other than Hashimotos?
  

[gimel]

Sent PM with info.

[jbjb5]

Thank you so much for all the information.  I'm in Fort Wayne, IN.  I'm working to get the earliest appointment possible between University of Michigan and an endocrinologist in Noblesville.  Any other suggestions?

[gimel]

Your symptoms and test results all add up to having hypothyroidism due to Hashimoto's Thyroiditis.  Hashi's is an autoimmune system disorder in which antibodies are produced that attack the thyroid gland until after usually an expended period, the gland is destroyed.  Along the way, thyroid medication is required and has to be gradually increased to offset the loss of natural thyroid hormone.  

I expect that your doctor has not given you any thyroid medication yet because he has the "Immaculate TSH Belief", and only wants to treat when TSH is above the range.  That doesn't work.  Or alternatively he uses "Reference Range Endocrinology", by which he believes that a thyroid test result that falls anywhere within the range is adequate.  That also is wrong because the ranges are far too broad.  The functional ranges for Free T3 and Free T4 are essentially the upper half of the reference ranges.  Many of our members report that symptom relief for them required that Free T3 was adjusted into the upper third of its range and Free T4 adjusted to around the middle of its range.

A good thyroid doctor will treat a hypo patient clinically by testing and adjusting Free T3 and Free T4 as necessary to relieve hypo symptoms, without being constrained by resultant TSH levels.  Symptom relief should be all important, not just test results.  You need to ask your doctor to start you on thyroid meds and keep adjusting the level as necessary to relieve symptoms.  If the doctor is unwilling to do this, then you will need to find a good thyroid doctor that will do so.  

The next time you go for tests, you should also request to be tested for Vitamin A, D, B12 and ferritin.  Hypo patients are also frequently low in the ranges for those tests as well.  If you decide you need a good thyroid doctor, if you will give us your location, members might be able to recommend one in your area.  

[jbjb5]

Sorry, the column line-up doesn't look anything like I typed.   My TSH numbers were 1.922 on 7/16 and 4.357 on 2/13.  My T3 Total was 90 on 7/16 and Free T4 was 1.12.  My TPO was 865 on 7/16 and 954 on 2/13.

[jbjb5]

Thank you so much.  Here is a copy of my spreadsheet The 1st set of numbers is the range given by the lab & then other columns are different dates' results.
                                  Range 7/162012 6/20/2012 2/13/2012
THYROID
TSH                 .4-5.3 1.922 4.357
T4 Total               4.5-12.5 6.9
Free T4                .8-1.76 1.12
T3 Total                60-200 90
Free T3                1.8-4.2 2.6
Thyroglobulin antibodies 0.0 - 40.00 <20
Thyroid Peroxidase Antibodies 0 - 35 865 954

[gimel]

I have no knowledge of anything related to kidney issues, but I can tell you that just because your thyroid test results are in the so-called "normal" range does not mean that is adequate for you.  The ranges are far too broad.    Many members, myself included, say that symptom relief  required that Free T3 was adjusted into the upper third of its range and Free T4 adjusted to around the middle of its range.

How long have you been having symptoms that might relate to thyroid issues?  

Symptoms such as mentioned are not a direct result of high TPO antibodies.  TPO ab is only an indicator of the level of activity of the antibodies that are attacking your thyroid gland due to Hashimoto's Thyroiditis.  Symptoms related to Hashi's come from inadequate levels of the thyroid hormones, primarily Free T3.  Free T3 largely regulates metabolism and many other body functions.  Scientific studies have shown that Free T3 correlated best with hypo symptoms, while Free T4 and TSH did not correlate.

If you will please post your thyroid test results that are supposedly "normal' members will be glad to assess the adequacy of your thyroid testing and treatment.