The instructions that came with my Thyroid medication say not to take your meds with Calcium or iron. I did some research online I found out that iron blocks the body's ability to absorb some of the hormone replacement. Calcium will neutralize some of the medication as well. So that ice cold glass of milk or that steak dinner with salad is detrimental to the amount of thyroid hormone in your bloodstream. Yes, this can affect your mood and energy level daily. Take it on an empty stomach 3 hours before or 3 hours after eating. I also found out that Cabbage, cauliflower, Soy, and broccoli can all depress the thyroid, so eat in moderation. I welcome any more information that you might have.