This is a question your mother should be asking her doctor.
I have taken Metformin & HCTZ with no symptoms.
When you're having any kind of diuretics, it is always possible to have low sodium, low potassium, low Mg (those must be controled).
About the side efects, all have, but Actos can give chest pain (general ill feeling), feeling short of breath, blurred vision. Actos is an oral diabetes medicine that help control blood sugar levels.These are serious allergic signs.
Lotrel (is used to treat high blood pressure ) can have as side effects chest pain muscle weakness, feel light - headed, fainting: Glempiride (for diabetes) can give dizzness or light headness; Crestor is to control cholesterol, have more offen side effects but doses of 10 mg are the lowest , and side effects can be abdominal pain (not chest). So is better to talk to the doctor about this side effects. She is very well medicated but allergic reactions can happen. TALK TO TE DOCTOR is all I can tell.