I am extremely depressed and am suffering with hypothyroidism, low testosterone, too much estrogen, high cholesterol and low Vitamin D what is wrong with me? I originally thought that everything here is linked to depression from stress and anxiety so I started taking Lexapro for the depression. But my wife thinks that maybe all of these things are linked to a health issue. About 11 months ago I was diagnosed with high cholesterol and low thyroid, so I am taking red rice yeast and .088 mg of Synthroid, then about 9 months ago I was diagnosed with low testosterone and was prescribed adrogel, which after reading the small print I decided not to use it. Six months ago I began getting depressed, re-evaluating life, ( 6 months from turning 50) and my self esteem began to drop and I have been in a downward spiral ever since. My wife had me go to a natural hormone doctor who ran blood work and said that my testosterone level was at 370 and I should be around 900 according to my age, my vitamin D level was very low and my estrogen was high, so I am on testosterone shots once a week, high once a week dose of vitamin D and Armidex for my estrogen level. I am taking 10 mgs of Lexapro but I don't feel a thing and have no idea if it is even helping but am afraid to quit. My wife says we don't know which came first the chicken or the egg, meaning if the depression caused the hormonal dysfunction or if a health problem is the cause of the depression, but she is concerned that the health issues may be overlooked due to the depression. What information can you give me.