I had been on generic Levothyroxine for a while, went from 25 mil to 50 then 75, then 100's This all prescribed by a GP that even stated my Thyroid was not enlarged, I started to tell him that the Society of Endocrinology had set new standards for the THS, from what they deemed normal around 5.0 was now 3.0, they based the average at a time when they did not realize how many people had Thyroid disorders, I began to talk to him about the new readings and he became all indignant and said I did not need to tell him his business (My body, his business, what a jerk) So I went to an Endo, he diagnosed me with Hashi's and said my yhyroid was inflamed and 2.5 times the size it should be, He also switched me from generic Levothyroxine 100's to Synthroid 100's and explained that when it comes to Thyroid medications that generics are "not" consistant in dose as Name Brand medications, I always had the understanding that generics and name brands were the same, Sure enough after six weeks my THS went from 6.0 down to 0.75 So I guess he was right, the generic was not changing mt THS very much at all, but the name brand made a big difference
I went the other way - from generic to Levoxyl. Six weeks later, my T3 and T4 had both gone down, even though the dose had remained constant. This indicated to me that the generic might have been a bit on the high side. My endo says the generic can vary as much as 15% from its stated dosage. So, if you were on 125mcg Synthroid and switched to generic (possibly containing 15% more - also could be 15% less), you'd be at approximately 144 mcg. That's a pretty big change. If you were doing well on the Synthroid, I'd definitely insist on being switched back.