My wife, aged 81 recently had a severe coughing spell. Our Dr. prescribed prednizol and a codine based cough medicine. The cough was cleared up. My wife was called back in 3 days later for her annual flu shot. A day later she has broken out with severe hives. Our MD is not available for a few days, so I thought I would investigate on my own. Could this be a reaction to the flu shot? The medication? Both? or something not related to either? I undeerstand and antihistine would help. Correct?