Chronic mouth and throat problems

[Margot49]

Well, I'll try this forum. I've posted in ENT and EPV forums.  I am still suffering from chronic dry mouth and throat issues. Set for yet another endoscopy on this Wednesday.  I doubt that is the problem. I have had many tests, biopsies, CT scans, MRI's, etc.  No definitive answers.  Whatever I *don't* have is now chronic and getting worse and just about ruins my daily life.
I am beginning to think that this is not necessarily an ENT  issue but has actually something to do with the *tissue* of my mouth and throat.  My tongue, palate and throat are mostly on the dry side, add to that a feeling of something stuck in my throat (more like a wad of mucus feeling), but my mouth and palate feel not only dry but like I have a mouth full of paste and absolutely nothing I use or do alleviates this problem.  It is so uncomfortable and it does cause me anxiety.  I have searched and searched the Internet and cannot really find anything that describes my symptoms. I have had two (parotid and salivary gland) biopsies plus blood work for Sjorgens, which were negative.  
I am really thinking there is something wrong with the *tissue* of my tongue, mouth and throat since the ENT docs really don't *see* anything bad, which is a good thing.  
Any ideas?  I don't even know what type of doctor I would consult with about this I go to the dentist regularly but he has  no idea what the problem is.
Also, I cannot find anyone I know or anyone who knows anyone with the symptoms I complain about.
Help.  :-(  There has to be a cause for this.  I am pretty much off all meds except for low dose Alprazolam (Xanax), which I've been taking for about 3 1/2 years.  I maybe take 1/2 a .5 mg tab twice, maybe 3 times  day.  
I can taste but drinking coffee, colas, eating, etc, seem to make it worse. This is very uncomfortable and I often almost loose my voice.  I've had a number of ENT docs look down my throat.

[Margot49]

Thank you for the response.  I have chronic dry mouth and throat and an almost constant feeling of nausea.  Had 2 biopsies and blood work for Sjogren's - negative.  Been treated for GERD by every ENT I've seen, no difference and, actually, had to stop Nexium as I got muscle pain and a rib fracture.  Saw an endocronologist and she is more concerned about Osteo and put me on 2000 iu of Vit D and checked my B12 and said that was ok.  Also had my second thyroid biopsy (nodules and cysts), benign.  I have overly good oral hygiene as I am constantly brushing my teeth or rinsing with something. I have to drink something constantly.  I've had brain MRI's and CT scans, no sign or stroke or TIA but I do have calcified plaque in the left carotid (the one that goes to the face).  cardiologist does not seem concerned about that.  Don't know about fungal infection but I am getting cold sores often.  One doc ran blood work and my Herpes and EBV were elevated.  My doc said that is no concern as you will see that in almost everyone.  I have had a *hard* heartbeat on and off for some time.  Have told my doc and he always says it is nerves. Told him again so he ordered a halter monitor and ECHO stress test.  I see him tomorrow. He actually called me at home on Saturday to tell me the ECHO  was abnormal and I need to see a cardiologist. I see him tomorrow.  Don't know why he had to call me and ruin my weekend as now I'm waiting to have a heart attack  :-(  I will not have an angio done.  I just do not feel well and whatever I don't have seems to now be chronic and worse.  Very depressing.  I h ave no idea what other doctor to see. I have seen probably a dozen in various specialties.  

[Dr. Kokil Mathur]

Hi
Welcome to the MedHelp forum!
Dry mouth could be the side effect of any medication you are taking. It could be due to Sjogren’s Syndrome but this will also cause dry eyes.
GERD or reflux disease too can cause similar symptoms. A generalized dehydration too can cause these problems.
Iron and vitamin deficiency, fungal infection, hypertension, diabetes, strokes and transient ischemic attacks, anemia, smoking all cause dry mouth. Poor oral hygiene is another cause. Nerve damage due to some trauma or surgery can be another cause.
Since I cannot examine you and know other related conditions you may be having, nor is a detailed history possible on net, I have listed the various possibilities that should be looked into. Please consult your PCP to run tests and examination(I know you have undergone loads) to clinch a diagnosis. Take care!