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Odd knee pain

Hello, my brother has had really bad knee pain for the past few years. It was often a sharp pain when he would work on his feet in a warehouse. When he wasn't at work it was constantly aching. The pain was in both knees and he didn't sustain any type of injury. Nothing he did helped much , pain meds, knee brace, stretching, it all helped a little bit but didn't drastically reduce his pain. The pain at times was unbearable for him. Eventually our grandma suggested he tried a gluten free diet. After a few weeks his pain was pretty much gone. It was really surprising to us because he doesn't have any digestive problems. But his pain eventually came back after several months and he still follows a gluten free diet.he doesn't even eat food that has been produced or handled in the same factory as anything with gluten He did mma for about 2 years and did 2 years of football before that. He had to quit all sports because of the pain. Then he started working in a warehouse and then he noticed the pain more. He's only 21 and an MRI showed smooth cartilage with no apparent injury. He doesn't smoke, drink or take any type of drug other than ibuprofen and has no other type of medical problem that we know of. He's stocky, 5'8 and about 190lbs. If anyone has any suggestions about how to alleviate the pain or what could possibly cause this we would be very great full. Thanks for your time
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