Prediabetic A1C, Sick Euthyroid, Headaches, Extreme fatigue -Cause?

[jadamson03]

My highly motiviated, determined daughter has spent the past 3-4 years with a series of worsening undiagnosed symptoms which has led to chronic headaches and fatigue to the point which she cannot go to school or work.  It started with breathing issues while taking part in basketball and track at 13 years old.  She then began to get debilitating headaches during and/or after exercise.  It continued to progress with extreme fatigue, rashes, strange metallic tastes (after exercise), difficulty falling asleep, extremely cold hands and feet, until this year she developed at headache in February that has never gone away.  Lately at 17 years of age, she can't even bring herself to get out of bed most days.  We have visited a pediatrician, reproductive endocrinologist, endocrinologist, cardiologist, dermatologist, neurologist, allergist, integrative general physician, holistic practitioner....etc.
First, they thought it was linked to elevated A1C (5.7-6.1) and iron-deficiency anemia (had an iron infusion), then her T3 became low, her ALT became elevated, then they found when ruling out PCOS that she has no detectable testosterone...and the list of abnormal tests goes on.  No one has been able to figure out the source Highlights: breathing problems, prediabetic A1C, low T3, no det. testosterone, etc...  Any ideas?

[Barb135]

In addition to Niko's suggestions have your daughter tested for a Hashimoto's Thyroiditis.

You didn't mention if they treated the low T3 or if they did further thyroid tests.

[TheLightSeeker]

Good point from  Barb.

I should add that Thyroid-resistance (type 2 ) due to possible undiagnosed  related imbalances needs to be ruled out. Suggested tests are Free T3, Free T4 and Reverse T3

Treating T3 with natural desiccated or synthetic thyroid  meds in this case might backfire, should  underlying  adrenal  issues are causing secondary hypothyroidism.

I won't get into the mechanics of this as it is very technical, but should you proceed with the above tests for her, please post the results  when they come back.

Also any  iron-related deficiencies, would have a direct impact on thyroid function.
This would make sense. should a pulmonary edema dx be considered (even sub-clinical), because of the resultant  decreased hemoglobin (which also plays  a role in the A1C test, giving a possible  false positive , thus erroneously indicating pre-diabetic state).

Keep us posted!

Best wishes,
Niko

[TheLightSeeker]

Good point from  Barb.

I should add that Thyroid-resistance (type 2 ) due to possible undiagnosed  related imbalances needs to be ruled out. Suggested tests are Free T3, Free T4 and Reverse T3

Treating T3 with natural desiccated or synthetic thyroid  meds in this case might backfire, should  underlying  adrenal  issues are causing secondary hypothyroidism.

I won't get into the mechanics of this as it is very technical, but should you proceed with the above tests for her, please post the results  when they come back.

Also any  iron-related deficiencies, would have a direct impact on thyroid function.
This would make sense. should a pulmonary edema dx be considered (even sub-clinical), because of the resultant  decreased hemoglobin (which also plays  a role in the A1C test, giving a possible  false positive , thus erroneously indicating pre-diabetic state).

Keep us posted!

Best wishes,
Niko

[TheLightSeeker]

Hi jadamson03.

The following conditions should be ruled out:

--Exercise-induced anaphylaxis.
Also Food-dependent exercise-induced anaphylaxis (It affects one–third to a half of patients with exercise-induced anaphylaxis.

--Subclinical* Pulmonary Edema  (measured in mmHg for pulmonary capillary wedge pressure (PCWP).
* PCWP at 11-12 mmHg.
This finding may put a number of patients at risk,  noting that Pulmonary Edema with  chest imaging  indicating  PCWP 8-12 mmHg is considered normal (grade 0 ) Not all patients at the upper end of the "normal range, are necessarily in the clear !
These numbers are only based on statistical data and in no way guarantee  absence of symptoms and disease involvement for everyone! Insist on revisiting  this, in the event it was already investigated and dismissed.

---Histamine Intolerance

---Mast Cell Activation Syndrome

-- Low Methylation (Conventional doctors know little about this and if the do they usually exercise intentional ignorance.
Easiest way to test is by getting  MMA and Homocystein Tests to check Methylocobalamin B12 and Methylfolate levels.

I hope this helps, however, my comments are not intended as a substitute for medical advice.

Niko