Undiagnosed Symptoms Community
25.2k Members
Avatar universal

Risk of Undetected Toxoplasmosis in Neutropenic or Immune-Suppressed Patients.

After her fourth course of chemotherapy in a clinical trial for Non Hodgkin's, T-cell peripheral lymphoma at a prestigious institute, my wife (aged 65) was declared in complete remission.  While neutropenic following her sixth course, she was hospitalized with a low-grade fever and remained febrile for sixteen days until her death which was attributed to hemophagocytosis.  Comprehensive testing during this time detected no bacterial, viral, or fungal infection, and no malignancy.  No malignancy was found in her subsequent autopsy.  What happened?  The autopsy concluded that dormant single-cell parasites, Toxoplasma gondii, had reactivated and that Toxoplasmosis drove the hemophagocytic syndrome.  The lymphoma and infectious disease diagnostic protocols where she was being treated did not include a test for the parasite or its disease.  Bactrim, given prophylactically to suppress pheumocystis carinii and which also suppressed the parasite during its administration, had been discontinued because she had allergic reaction to it.  The drug substituted for Bactrim, pentamidine, has no effect on the parasite.

I want to get the word out that chemotherapy or other immune-suppressed patients who develop a fever should be proactive in prompting their Attending Physicians to consider parasites, and to assume that standard diagnostic protocols are not designed to automatically test for them.   My goal is to get this central message widely disseminated since it will take at least six months for the institute to get the case published.  .
0 Responses
Top General Health Answerers
363281 tn?1590104173
Nelson, New Zealand
1756321 tn?1547095325
Queensland, Australia
19694731 tn?1482849837
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
In this unique and fascinating report from Missouri Medicine, world-renowned expert Dr. Raymond Moody examines what really happens when we almost die.
Think a loved one may be experiencing hearing loss? Here are five warning signs to watch for.
When it comes to your health, timing is everything
We’ve got a crash course on metabolism basics.
Learn what you can do to avoid ski injury and other common winter sports injury.
Here are the pros and cons of the top fad diets and weight loss plans of the year.