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frequent urination NSAIDs

Please refer to article from Medline "Cyclo-Oxygenase- and Capsaicin-Sensitive Afferant Febres Affect Beta-Adrenoceptor-Evokeked Response in the Rat Urinary Bladder" key word: NSAIDs Tucci (author), Indimetacin.

Ok, after taken 1000 mg (never had this dose level before) of Ibuprofen, I had began to experience frequent urination that night.  Not realizing a possible connection, I took the same dose again the following day and 3 celebrex (1 day dose)during that week.  Problem with frequent urination continues six weeks later.  6-7x a night at minimum. Problem also during the day.

I should note that I have been previously diagnosed as having tight bladder neck muscle, so I generally did not empty my bladder in tests (assume it was 1/2 full).

I understand correlation vs. causation.  Having said that I believe it is possible that the the Ibuprofen/Celebrex (3% or more in pure form is excreted in urine (who knows what effect the metabolites still have) stayed in the urine in my bladder for undue time and is the cause of my current problem.  Explain to me why this is not a possible cause (that is damage was done to the beta-adrenoceptors) or some other damage was done.
2 Responses
233190 tn?1278553401
Here are the side effects of ibuprofen from the Drug Information Handbook:
"1% to 10%:
Central nervous system: Headache (1% to 3%), nervousness (<3%), fatigue (<3%)
Dermatologic: Itching (1% to 3%), rash (3% to 9%), urticaria
Endocrine & metabolic: Fluid retention
Gastrointestinal: Dyspepsia (1% to 3%), vomiting (1% to 3%), abdominal pain/cramps/distress (1% to 3%), peptic ulcer, GI bleed, GI perforation, heartburn, nausea (3% to 9%), diarrhea (1% to 3%), constipation (1% to 3%), flatulence (1% to 3%), indigestion (1% to 3%)
Otic: Tinnitus

<1% (Limited to important or life-threatening): Acute renal failure, agranulocytosis, angioedema, aplastic anemia, arrhythmias, aseptic meningitis with fever and coma, bone marrow depression, CHF, dyspnea, eosinophilia, erythema multiforme, hemolytic anemia, Henoch-Schonlein vasculitis, hepatitis, hypertension, leukopenia, lupus erythematosus syndrome, neutropenia, Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis"

The following is the side effects for Celebrex from the same source:
">10%: Central nervous system: Headache (15.8%)

2% to 10%:
Cardiovascular: Peripheral edema (2.1%)
Central nervous system: Insomnia (2.3%), dizziness (2%)
Dermatologic : Skin rash (2.2%)
Gastrointestinal: Dyspepsia (8.8%), diarrhea (5.6%), abdominal pain (4.1%), nausea (3.5%), flatulence (2.2%)
Neuromuscular & skeletal: Back pain (2.8%)
Respiratory: Upper respiratory tract infection (8.1%), sinusitis (5%), pharyngitis (2.3%), rhinitis (2%)
Miscellaneous: Accidental injury (2.9%)

<2%, postmarketing, and/or case reports (limited to important or life-threatening): Acute renal failure, agranulocytosis, albuminuria, allergic reactions, alopecia, anaphylactoid reactions, angioedema, aplastic anemia, arthralgia, aseptic meningitis, ataxia, bronchospasm, cerebrovascular accident, CHF, colitis, conjunctivitis, cystitis, deafness, diabetes mellitus, dyspnea, dysuria, ecchymosis, erythema multiforme, esophageal perforation, esophagitis, exfoliative dermatitis, flu-like syndrome, gangrene, gastroenteritis, gastroesophageal reflux, gastrointestinal bleeding, glaucoma, hematuria, hepatic failure, hepatitis, hypertension, hypoglycemia, hypokalemia, hyponatremia, interstitial nephritis, intestinal perforation, jaundice, leukopenia, melena, migraine, myalgia, myocardial infarction, neuralgia, neuropathy, pancreatitis, pancytopenia, paresthesia, photosensitivity, prostate disorder, pulmonary embolism, rash, renal calculi, sepsis, Stevens-Johnson syndrome, stomatitis, sudden death, syncope, thrombocytopenia, thrombophlebitis, tinnitus, toxic epidermal necrolysis, urticaria, vaginal bleeding, vaginitis, vasculitis, ventricular fibrillation, vertigo, vomiting"

Thus, although it is possible, urinary frequency is not a noted side effect of ibuprofen or celebrex.  I would investigate more frequent causes of urinary frequency before attributing it to the medications.  This would include diabetes, infection or kidney dysfunction.  If the ibuprofen or celebrex led the kindey dysfunction (as measured by the creatinine clearance), then it is possible that the urinary output could be affected.

Followup with your personal physician is essential.

This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
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