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tygacil - how to administer

Dear Doctor,


I have a year-long infection of urinary tract caused by two pathogens: coli and faecalis which do not respond to the treatment of antibiotics from different groups presribed on the basis of the smear test results.

I would like to take tygacil as this is a highly innovative medicine overcoming the existence of pumps in bacteria and getting rid of the ribosome protection.

I  do not know, however, how it should be administered: through an IV cannula or through a PICC line
I have heard from somebody that it should by no means be administered through an IV cannula as it can literally burn the veins and even put life at risk. One private hospital that I have addressed the question to said that it could be administered through the cannula, not the PICC line.
Could you please tell me what is the right method of administering this drug and what side effects it has.

Is that comparable with imipenem?

I am about to take this drug so your response would be of great help to me.

Thank you in advance for shedding light on this. .
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Avatar universal
Dear Doctor,

Thank you so much for posting the answer to my urgent inquiry.
May I ask you one more question which would be crucial in deciding about my treatment plan.
Do you think that tygacil would be effective in eradicating the bacteria residing in the urinary tract. Normally, according to the information leaflet accompanying the medication it is destined for treating very difficult cases of abdominal infection although the bacteria killing proccess that it nicely initiates can relate to other cases e.g. such as mine.

The mechanism that this medication employs to kill the bacteria (overcoming the bacteries' pumps as well as reaching the bactieries' rybosome) makes it very unique and stand out in the group of IV medicine.
Hence this decision to use it in my case but your thoughts and insight would be much appreciated before I venture on this difficult path.
Looking forward to hearing your view on this:)

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563773 tn?1374246539
MEDICAL PROFESSIONAL
Hello,
Thanks for posting your query.

Tygacil contains tigecycline which is a tetracycline antibiotic. It should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. The drug is given intravenously. However if multiple drugs are to be given then drugs like amphotericin B, amphotericin B lipid complex, diazepam, esomeprazole and omeprazole should not be given through the same I/V cannula.

The side effects of Tygacil are similar to tetracyclines and include diarrhea, nausea and vomiting. Other common side effects are those related to administration of injection like pain at injection site, swelling and irritation; increased or decreased heart rate and infections.

Mode of action of Tygacil is different than Imipenam and they cannot be compared but studies have shown that tigecycline is less efficacious than imipenem in the treatment of experimental pneumonia.

Hope that this information helps and hope that you will get better soon.

Wishing you good health.






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