I'm assuming you know your B6 levels are too high because a doctor tested you. Did you ask the doctor these questions? Some of the things you mention, the neuropathy, can be caused by a B6 overdose, but that usually happens in people who supplement. B6 is in balance with folic acid and B12 -- what were your levels of those nutrients? One way to lower your B6 is to take more of those two nutrients. Also, look at your diet and see what you're eating that might contain an imbalance of B6. Now, tyrosine can cause some of these problems as well, such as the anxiety and anxiety-related symptoms. B6 is necessary for tyrosine to work, and you have plenty of it, so you're probably absorbing that tyrosine pretty well. How long has this been going on? Did it start when you started taking the tyrosine? In any event, it wouldn't hurt to stop taking it for a couple weeks and see if some of the problems go away. As for cortisol, that's a hard thing to measure -- it might be low at the moment you had your blood test and it might be high an hour later. It varies through the day and depending on how much stress you have to handle. But if it is low on a consistent basis, that indicates a problem with the adrenal glands, which can also indicate a thyroid problem. Again, what does your doctor say?