I'm a 42 year old female. Hysterectomy (everything removed), appendectomy some 10 years ago without HRT. Over the last 14 months I have had two episodes of extreme bladder spasm (last about a week of intense pain) followed by numbness and tingling on the lower extremities (saddle area through parts of the inner legs and big toes -bilateral) which takes weeks to go away. I had a full work up -MRI, blood work, spinal tap (only showed identical oligoclonal banding -which is indicative of some type of systemic inflammation). I have been evaluated for autoimmune as well. NOTHING!. I've been to neurology, urology (dx of irritable bladder), and GYN (thinks adhesion in abdomen from multiple abdominal surgeries). However, no one has figured out this particular condition of extreme bladder spasm followed by numbness and tingling bilaterally in the legs. This is my frustration. This time around, I went to the ER for the pain and they prescribed pain killers. They didn't run any tests other than blood work and decided not to do a scan because of all of the work the year prior and wanted me to follow-up with GYN. I appreciate the pain killer -but I want to know WHY this is happening. The last round of experts didn't help. I have some scar tissue on the S1 nerve root from back surgery -also about 10 year ago -but the MRI didn't show anything that would explain what is happening. It is incredibly unnerving to loose sensation in your lower extremities following a week of extreme lower pelvic pain -with no answers. Does anyone out there have any ideas?