Thank you very much for your good answer.
Hi. I can tell you as a married woman, it is important for one's spouse to love them as they are. It feels horrible for someone to be plotting on how to change you especially one's physical appearance. There are no pills or creams that reduce (or enhance) breast size. If her breast size is causing HER discomfort such as back pain, she can have surgical breast reduction. Or if she is gaining breast size as she gains weight, losing weight will also reduce them. But overall, your job is to love your wife and make her feel good about herself rather than trying to change her. good luck