I am currently taking prednisone 10mg and methotrexate once a week. I have been on it almost 3 months and am beginning to see some improvement. I have less redness and have actually gone longer between drainings than I have since January (over 4 weeks so far). No miracles yet but my rheumatologist says it can take 3-6 months for methotrexate to really take effect and see improvement. As for side effects the prednisone is worse in my experience I have hot flashes and mood swings and its put a stand still on my weight loss and gives me horrible anxiety. The methotrexate makes me feel tired on the day I take it and my hair is thinning but both are tolerable. The plan is to lower the prednisone and up the methotrexate later this month. I'm willing to try anything and there is some research out there on the combo that is hopeful. But this is up to u I think there's no easy answers and everyone has different experiences with meds and this disease.
Fibromommy:
Before I started on 40 mg prednisone my breast was a disaster and the pain was maddening. The drug was very effective until we tapered down to 20 mg. At that point the disease started coming back. So we went back to 30 for awhile, I started improving, and we again started to taper, this time with methotrexate added.
I am wondering if 5 mg prednisone would have any effect at all? If you were on higher doses of prednisone, you might see some results. And you might go crazy! It's a very unpleasant drug. If your personality changes, and it can, it can screw up important relationships.
Imuran - I don't know what that is. However, you if are worried about your hair, methotrexate really makes it fall out (it did for me). Methotrexate, if you take it once a week like I did, may give you flu symptoms the evening you take it. I "had the flu" once a week and had to go to bed in the early evening. I think that's a pretty severe side effect.
In the end, I wasn't cured by either prednisone or methotrexate. My doc took me off both drugs and we expected me to start getting the disease back in full force. However I put a stop to that with healing clay (calcium bentonite), which I have been using for months. No pain, no new cysts, and the two old cysts which never properly drained are little hard painless things that are slowly getting better.
Can't give you any advise. I am non-compliant. I am on 30mg of Prednisone. I am on week 4. I saw little in the way of results till the end of week 2. The first time I was on Prednisone I was on 20mg for 14 days. Things quieted, but didn't go away. It did, however, take the anger out of the symptoms. This time we are leaving me on till I can see the Rheumatologist. My breasts are improving in shape and color, and the big lump in the middle seems to be softening....but you know how we get about feeling our breasts all the time.