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1723069 tn?1340557749

Methotrexate

Hello Ladies,
my daughter started Prednisone, one month ago, and his doctor wants to give her methotrexate, we would like to know more about the last medicine, ( opinions ) what is, and who in the forum have experience with the methotrexate, side efects etc

Thank you
8 Responses
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1627204 tn?1302012537
I have now starting my 5th week on these drugs. I can honestly say I have had no serious side effects. It can be a little hard to tell, because the heat of July was almost unbearable...even inside with air-conditioning it is quite humid, so I have a hard time gaugeing if I am haveing hot flashes, or if it is just hot and stuffy.
My apt. with my Rheumy is the 18th. I suspect we will check blood work and adjust med. The girls are feeling close to normal. Scarred, but soft.
Helpful - 0
1723069 tn?1340557749
thank you for this information my daughter is scared of Chemotherapy medications.
this forum is a great help
Helpful - 0
1657910 tn?1302372061
Hi Dad,

I am just catching up with your story as I have been away for a while.  Just another option that you might look into is Imuran.  It works like Methotrexate, but my doctor preferred me to use it because of my age and child baring years.  I am 33 and been dealing with it for over a year.  

The Imuran does have bad side effects like the Methotrexate, but it might be another option for your daughter.  I started at 50 mg a day, then 100, just recently went to 150 but my body couldn't talerate it so I am back down to 100 mg.  The highest dose my doc said he had ever used was 200mg so I am right in the middle.

Fibromommyx3
Helpful - 0
1627204 tn?1302012537
My doctor did a really good job of explaining...but it has been 3 weeks plus since I have seen him...so I will try to tell you what I remember. He implied that the Granulomous disceases are an abnomality of the T-cells in our blood. The Methotrexate goes after the recent abnormal growth of the blood cell. That is why they use it to fight psorisis and breast cancer. It is also used very successfully in fighting Rheumatoid Arthritis. One of my mothers friends said that when she started going in once a week for Methotrexate injections for RA, she felt 10 years younger.
Helpful - 0
1723069 tn?1340557749
I found  other  interesting conversation in this forum  initiated by Jojo45
Treatment with Methotrexate Alone

http://www.medhelp.org/posts/granulomatous-mastitis/Treatment-with-Methotrexate-Alone---Have-you-Seen-This-Article/show/1160275
Helpful - 0
1723069 tn?1340557749
Prednisone is is an anti inflammatory medication, how works methotrexate with the this  illness ?

Ladies thank you for your opinions
Helpful - 0
1548207 tn?1303454180
I have been on methotrexate for about 5 months now. I was taking 3 pills one time a week and 10mg of prednisone daily and folic acid daily. My doc says it takes up to 3 months to have the drug fully in your system to begin working which is why he paired it with the prednisone. We just changed my doses 3 weeks ago and increased to 5 pills a week of methotrexate, folic acid daily, and I am currently slow dosing off of the prednisone (we decrease the dose a week at a time).

In the last few months i have had some improvement and my need for drainings have become less often I have gone 5 weeks at one point between drainings when i was going weekly in feb. Its no miracle but i am seeing improvement and my rheumatologist is optimistic that i will continue to see improvement as we adjust dosing and reevaluate in October. He expects the methotrexate to do the long term heavy lifting and be one it for at least a year. I actually just found a new lump this weekend and am going to have it checked tomorrow morning by my breast specialist but its smaller that previous ones so I am being hopefull.

As for side effects they arent too bad compared to the prednisone or the disease itself honestly. I take mine in the afternoon after lunch on the day I take it because i tend to be more tired the day I take it and the following day. I have had some thinning of my hair but not very noticable I take a prenatal vitamin to help withthe hair growth and just general health, they tend to have more iron than regular vitamins. Since we upped my dose i am having some nausea the following 1-3 days but my doc thinks it will subside as my body adjusts to the new dose. Mouth sores are also a common side effect and i do get them occasionally but they heal within a day or two so they arent too bad.

Like Pandora mentioned be weary of the sun while on it. Also it can effect your liver function so they recommend to avoid alcohol and they test the liver function( we did every 3-4 weeks the first 4 months and now every 8 weeks). Also it is a class X drug so it is not recommened for women nursing or planning to become pregnant and my doc went as far as to recommend an iud to ensure i wont become pregnant although i opted to continue my low hormone birth control.

Anyway hope u find this helpful

Helpful - 0
1627204 tn?1302012537
Hi Dad, Glad to hear from you.
I started Methotrexate 3 weeks ago. I take 6 tiny pills 1x a week. I plan to be on it for at least 6 month. My doctor said this is a Medium dose. To read about the drug and its possible side effects is scarey indeed. However, my doctor uses it himself for his own auto-immune issues, and feels it is very safe and very effective. He plans to wean me off the prednisone next month, and says that because of the Methotrexate, we should be able to wean without the typical backlash (flare-up of symptoms).
I always make sure I eat before I take my meds. So far I have had no issues with side effects. I am careful to stay in the shade and use sunscreen, since it is supposed to  increase sensitivity to sun. He has me on Plaquim and Folic Acid and Vit C with the Methotrexate.
I think I am doing well on this. No new flare ups, and the girls are starting to look and fell normal again.
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