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What do you take to support cell function and oxidative phosphorylation?
Anyone, what supplements do you take to support cell function and oxidative phosphorylation? The reason I'm asking is because I recently found out there is a genetic researcher nearby who is researching anti-oxidant therapy and glutathione for mitochondrial disorders. I have an appointment with him for my son, in November.
My son has not been diagnosed with a mitochondrial disease, but he had organic acids tests done, by a nutritionist, for suspected nutrient deficiencies. He has 14 abnormalities on these tests, indicating cell dysfunction, significant oxidative stress and glutathione loss. The nutritionist supplied many supplements, based on the test results, to replace his low nutrients, and to help support oxidative phosphorylation - such as CoQ10, N- Acetyl - L-Cysteine, glutathione and other specific amino acids, vitamins and minerals.
I showed these tests to my son's doctors but they have ignored them, and even told me that they do not know how to interpret them. (I'm glad we finally have an appointment with a geneticist!)
My son had a pituitary cyst, which caused severe endocrine hormone deficiencies, but his doctors are reluctant to diagnose any other condition besides the pituitary damage and hormone loss. All of my reading this year leads me to believe that his cell dysfunction and nutrient deficiencies could be the result of severe growth hormone deficiency, but his docs don't know.
He has severe orthostatic intolerance, which has not yet been treated with any medication (although he is on cortisol and thyroid replacement hormones). This problem began 9 months before the surgery to remove the cyst, and did not improve, or worsen after surgery. I believe he has autonomic dysfunction, but his doctors don't all agree. I believe that, like myself, they are hoping his condition improves after he starts growth hormone therapy, but still they say they do not have any other patients with his symptoms (even though OI is not uncommon with adrenal insufficiency).
One doctor recently said she suspects my son may have Ehlers-Danlos Syndrome, due to his hyperflexable joints, but I think he has connective tissue breakdown due to his nutrient deficiencies and growth hormone loss. He also had a high ANA titer of 1280, suggesting an autoimmune disorder, but again, this could just be a reflection of the pathology of severe growth hormone deficiency.
If a genetic cause is found for my son's severe symptoms, I think these supplements will be crucial in helping him regain his mobility and health.
I was hoping all of the recommended supplements would improve my son's symptoms, but he will not take most of them, so I wanted to ask others, with confirmed mitochondrial dysfunction, if your supplements are helping you.
Enzymelover
My son has not been diagnosed with a mitochondrial disease, but he had organic acids tests done, by a nutritionist, for suspected nutrient deficiencies. He has 14 abnormalities on these tests, indicating cell dysfunction, significant oxidative stress and glutathione loss. The nutritionist supplied many supplements, based on the test results, to replace his low nutrients, and to help support oxidative phosphorylation - such as CoQ10, N- Acetyl - L-Cysteine, glutathione and other specific amino acids, vitamins and minerals.
I showed these tests to my son's doctors but they have ignored them, and even told me that they do not know how to interpret them. (I'm glad we finally have an appointment with a geneticist!)
My son had a pituitary cyst, which caused severe endocrine hormone deficiencies, but his doctors are reluctant to diagnose any other condition besides the pituitary damage and hormone loss. All of my reading this year leads me to believe that his cell dysfunction and nutrient deficiencies could be the result of severe growth hormone deficiency, but his docs don't know.
He has severe orthostatic intolerance, which has not yet been treated with any medication (although he is on cortisol and thyroid replacement hormones). This problem began 9 months before the surgery to remove the cyst, and did not improve, or worsen after surgery. I believe he has autonomic dysfunction, but his doctors don't all agree. I believe that, like myself, they are hoping his condition improves after he starts growth hormone therapy, but still they say they do not have any other patients with his symptoms (even though OI is not uncommon with adrenal insufficiency).
One doctor recently said she suspects my son may have Ehlers-Danlos Syndrome, due to his hyperflexable joints, but I think he has connective tissue breakdown due to his nutrient deficiencies and growth hormone loss. He also had a high ANA titer of 1280, suggesting an autoimmune disorder, but again, this could just be a reflection of the pathology of severe growth hormone deficiency.
If a genetic cause is found for my son's severe symptoms, I think these supplements will be crucial in helping him regain his mobility and health.
I was hoping all of the recommended supplements would improve my son's symptoms, but he will not take most of them, so I wanted to ask others, with confirmed mitochondrial dysfunction, if your supplements are helping you.
Enzymelover
Thank you for your reply. I am so sorry that you are having so much trouble from your illness. Have you been tested for glutathione deficiency? There are two specific metabolites that supposedly indicate glutathione loss and a need for glutathione supplementation to assist proper detoxification. These are pyroglutamate, and a-Hydroxybutyrate.
My son's urine organic acids test showed very high levels of these metabolites and others, such as 8-Hydroxy-2-deoxyguanosine, which is a DNA oxidation product that can indicate oxidative damage within the cells.
I hope the geneticist will be able to tell whether his tests indicate a possible genetic breakdown, or only nutrient deficiencies.
Are you normally ambulatory, or is walking difficult for you? Does your Mito Disease have a label, or does your doctor call it a generalized mitochondrial dysfunction? I am trying to understand how a mitochondrial disease might fit with my son's condition.
I hope you are feeling better today!
My son's urine organic acids test showed very high levels of these metabolites and others, such as 8-Hydroxy-2-deoxyguanosine, which is a DNA oxidation product that can indicate oxidative damage within the cells.
I hope the geneticist will be able to tell whether his tests indicate a possible genetic breakdown, or only nutrient deficiencies.
Are you normally ambulatory, or is walking difficult for you? Does your Mito Disease have a label, or does your doctor call it a generalized mitochondrial dysfunction? I am trying to understand how a mitochondrial disease might fit with my son's condition.
I hope you are feeling better today!
I do take Cq10, Carnitor, high dose of B2. They call this the Mito Cocktail for the Mito disorder that I have. I am other meds also for other issues but once a cell has been destroyed it can not be restored. I hope you can get some answers when you see this genetic dr in November.
Joyful50
I do apologize for the long wait for an answer, been in a crash for the last few weeks. that means that I am unable to do anything but rest until my body can function again. Stress brought this on this time.
Joyful50
I do apologize for the long wait for an answer, been in a crash for the last few weeks. that means that I am unable to do anything but rest until my body can function again. Stress brought this on this time.
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