Hi Dave, I have had a recent onset of what seems to be similar to RLS. Unfortunately, I don't think it will be of much help to you other than knowing maybe there are others out there. I had a successful surgery on a tib-fib fracture in 2003 with 2 titanium plates and 17 screws. I had successful rehab and returned to almost 100% function. About 2 years ago, I started having occasional RLS-type feelings in that leg only (and also limited to the area around the surgery). Thankfully, it doesn't happen often and I have not needed medication, but it does concern me. If it increases, will I need to explore medication or should I discuss removing the titanium (if possible)? I don't want to sound like an internet doctor, but there are so many materials (nickel, gold, acrylates) that can cause allergies well after they are put in a body. Is titanium one of them? I hope not, but just want to share my experience. I hope you have found an answer since you posted.