Is there a new depression medication for treatment resistant depression?

[Poo44clooner]

I have treatment-resistant depression and am only on Extended Release Ritalin 20 mg in the morning and 10 mg Ritalin at noon. It was working fine for several months but recently my depression has come back with a vengeance and I am not doing well. I am struggling daily and every aspect of my life has been affected even my sleep and eating habits. My psychiatrist who has been treating me has left the group practice and my last visit with her she said that she was not going to prescribe me anything because of my history of medications not working even ECTs and TMS. I am going to see another psychiatrist in about a week and I hope he prescribes me something that might lift some of my deep depression. Does anyone have treatment-resistant depression and know of any medication that does help?

[Poo44clooner]

During my sleep study last Saturday night the first portion of the study they had me sleep without the biPAP machine and I woke up 3 times choking and gasping for air. I called for the tech to hook me up to the machine but he said that he couldn't because I had another hr to be off the machine. It was a rough night. Then during the next part of the night he hooked me up to the machine and I slept better but I still woke up exhausted and said so in the survey before I left the sleep study.

[Paxiled]

Could be a lot of things.  Could be you've been treating this with speed and the speed has stopped working and now you're suffering the rebound many people get when they take speed.  Ritalin is speed.  It can be the cause of lack of sleep.  It can also cause anxiety, though you don't say that's a problem.  If you tell us what medications and what types of therapy you've tried somebody might have something new to suggest.  If you do have sleep apnea, it can be the cause of a lot of problems.  It can also be irrelevant and overdiagnosed, but when it is the problem, it is the problem.

[Poo44clooner]

I do have sleep apnea and have been using biPAP machine for years.  Just recently I found out that I have been dipping in lows 80s and even down to 77% during my sleep which I hope would explain my exhaustion and decrease in energy and maybe making my depression worse.
I have been on all kinds of drugs. Too numerous to say or even remember. I had tremendous success with Parnate but that worked for about 8 to 9 months and I became worse thereafter.  I was put on Abilify which didn't work. They have put me on old antidepressants and even newer ones. My psychiatrist didn't want to try to even put me on any antidepressant because of my history with being treatment-resistant.
Just asking if anyone out there is in my position who has had success with any type of antidepressant of any kind.
My depression is now affecting my sleep even though I am on 2 kinds of meds to help me sleep which have been working very well until now. I do wake up during the night with such deep dark depression that it is so unbearable.

[octaputer]

Modafinal  a/k/a. Armodafinal or provigil.  Same thing, but my original dosage, to get me through the day was 1000 I now take Armodafinal 250 mlg, 3 times a day.

[Poo44clooner]

Thank you for your comment. Has provigil been helping you with your depression and for how long? I will certainly tell my psychiatrist about this.
Thank you

[Poo44clooner]

Just a follow-up to my question I forgot to say that in the past few months I awake exhausted and stay exhausted all day and I don't take any tranquilizera. I recently had an overnight pulse oximetry test done and it revealed that during my sleep my oxygen dips into the low 80s and even as low as 77%. So they ordered a sleep study and I took it last Saturday night. I go for my sleep study results in 2 wks. I don't know if this oxygen issue during my sleep has anything with the resurgence of my deep depression.
Any thoughts?