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Should I take my pfizer covid 19 vaccine after a single dexamethasone shot ?
My doctor had the sister administer a single dexamethasone shot 4 mg & Lyncmicin because I was having a cold. This was my 1st time receiving immune suppressant, I am young 32, healthy. I was fully immunized in July 2020, pfizer shots both.
I had some concerns as I got a flu shot and am scheduled for my Pfizer covid booster in a couple of days. What they told me was that they did have at one time a recommendation to have 14 days between shots. But that now, you can get them closer without issue. They do not interact. However, they like to do them in separate arms. So, I'll have flu in left arm and they will give covid in my right. Because some develop pain and rash and they want to know which vaccine caused it.
Now, I DID find this. https://www.mayoclinic.org/drugs-supplements/dexamethasone-oral-route/precautions/drg-20075207 That is for the oral dexamethasone. But they don't want you to get any vaccines while on that unless a doctor approves it. Different than an injection but I would most certainly run it past your doctor before your vaccine to make sure.
Now, I DID find this. https://www.mayoclinic.org/drugs-supplements/dexamethasone-oral-route/precautions/drg-20075207 That is for the oral dexamethasone. But they don't want you to get any vaccines while on that unless a doctor approves it. Different than an injection but I would most certainly run it past your doctor before your vaccine to make sure.
3 Comments
I wouldn't run anything by that particular doctor. He sounds like he doesn't know what he's doing.
I did change. The new one told me it's okay to take 3rd dose. But these guys are only GP, not immunologist, I am not afraid of the dose, I have no allergic reactions to anything. The question is has this steroid injection reduced my antibodies gained by the vaccine primary vaccination.
If that's your question, no. What is more likely is that it has reduced your immunity to fungal infections, sinus infections, ear infections, things like that. Covid is so contagious at this point in time even fully vaccinated people can get it but you will be protected from severe illness. The vax gives your body muscle memory so it'll recognize the spike protein and go into action. What you took won't affect that. Peace.
This doesn't make any sense. If you mean lincoycin, that's a very strong antibiotic and doesn't treat viruses, it treats bacterial infections that are resistant to other antibiotics. You also wouldn't get a steroid for a cold. Neither of these would be used for the very mild common cold, you'd be told to go home, rest, and drink plenty of liquids. You might contact your doctor and see just exactly what you were treated for, as it might help answer your question. Steroids do suppress the immune system but this one is being used for serious covid illnesses. But again, the other one wouldn't be used for covid either.
8 Comments
he is a young GP, and for common cold, which he thinks it might be covid 19, he administers an injection of dexamethasone/lincomycin. I have asked before administering and after, I get it his choice is weird, but that's what he did. It was a hip injection shot. Now, what do you guys think, will dexamethasone would affect Pfizer vaccine efficacy, and yes I am changing my GP.
You don't say when you had the steroid injection, but a brief internet search shows that orthopedic surgeons, who use a lot of corticosteroid injections, recommend apparently from a CDC recommendation that you wait two weeks after a steroid injection to get a vaccine and don't get another for one week after the vaccine. There's apparently no proof of negating vaccine immunity, but given steroids are immune suppressants they're being cautious with this advice. So there you go. And never see that doc again, as there are negative effects of both steroids and antibiotics and both should only be taken when absolutely necessary. If the doc thought you had covid he should have tested you for it both with a rapid antibody test which isn't super accurate but is pretty accurate and also a more accurate PCR test before giving you treatment. That steroid is used for covid patients, but I think only when they have some pretty strong symptoms including breathing difficulties. The drug you should have taken assuming he tested you for covid and you had it would have been the monoclonal antibodies, and there are two pills that are being given emergency approval that are one not very effective anti-viral from Merck and one very effective drug from Pfizer at least in the small clinical trials they did as these when they work and the monoclonals and the Pfizer pill apparently work about 85% of the time prevent any serious disease. The steroid is for symptoms when they're bad. That doc's a quack. Peace.
yeah, true. It's been 3 days since he injected that 4mg Dexamethasone dosage. I am okay now, no cough, or any other cold symptoms. Based on what I#ve read he has made a huge mistake, you don't just inject a very very potent Dexa (I figured is very potent) to a patient complaining for nose congestion and cold, no temperature whatsoever. My last pfizer dose/2nd is 31 july, But now I found out from some sources that Dexa could affect HPA Axis and reduce antibodies .
Am I vulnerable now of contracting covid19 ?
https://www.cuimc.columbia.edu/rehab/sites/default/files/documents/steroids_and_vaccination.pdf
''. Given that the ability of antigen presenting cells to activate naïve T cells is vital to initiating the adaptive immune response, the presence of corticosteroids could impair this process.
Even though memory T and B cells may start forming early in the response, they continue to
differentiate and proliferate over several weeks [6,7,8]. Corticosteroids may also affect memory
cells once they are generated. Although it is possible that some memory cells are more resistant to
such insult, recent data suggest that CD8+ T cell memory may be more sensitive [9,10]. Importantly,
these effects are dependent on corticosteroid half-life. For example, if the half-life of a long-acting
corticosteroid is (at most) three days, its levels will be reduced 1000-fold, four weeks after
administration (and close to 100-fold, two to three weeks after). This will reduce the effects on
immune response dramatically. Table 1 shows the duration of action of various corticosteroids
used in clinical settings [11]
Am I vulnerable now of contracting covid19 ?
https://www.cuimc.columbia.edu/rehab/sites/default/files/documents/steroids_and_vaccination.pdf
''. Given that the ability of antigen presenting cells to activate naïve T cells is vital to initiating the adaptive immune response, the presence of corticosteroids could impair this process.
Even though memory T and B cells may start forming early in the response, they continue to
differentiate and proliferate over several weeks [6,7,8]. Corticosteroids may also affect memory
cells once they are generated. Although it is possible that some memory cells are more resistant to
such insult, recent data suggest that CD8+ T cell memory may be more sensitive [9,10]. Importantly,
these effects are dependent on corticosteroid half-life. For example, if the half-life of a long-acting
corticosteroid is (at most) three days, its levels will be reduced 1000-fold, four weeks after
administration (and close to 100-fold, two to three weeks after). This will reduce the effects on
immune response dramatically. Table 1 shows the duration of action of various corticosteroids
used in clinical settings [11]
Well, frankly, we're all vulnerable, but you've been vaccinated so I wouldn't worry, just take precautions, wear your mask, etc. You can help yourself some by going to the best health food store near you and buy the best multi-spectrum probiotic from the refrigerated section of the supplement dept. You'll be fine most likely and you'll know if you aren't if you start getting things like fungal infections or things like that. Probably you won't. But covid, by this point in time again we can all get it, so just be careful and when you can, get your booster. Peace.
Thank you a lot. It's just I read this, and here it says that it affects memory cells as well, so I don't know what to do.
''. Given that the ability of antigen presenting cells to activate naïve T cells is vital to initiating the adaptive immune response, the presence of corticosteroids could impair this process. Even though memory T and B cells may start forming early in the response, they continue to differentiate and proliferate over several weeks [6,7,8]. Corticosteroids may also affect memory cells once they are generated. Although it is possible that some memory cells are more resistant to such insult, recent data suggest that CD8+ T cell memory may be more sensitive [9,10]. Importantly, these
effects are dependent on corticosteroid half-life. For example, if the half-life of a long-acting
corticosteroid is (at most) three days, its levels will be reduced 1000-fold, four weeks after administration (and close to 100-fold, two to three weeks after). This will reduce the effects on
immune response dramatically. Table 1 shows the duration of action of various corticosteroids
used in clinical settings [11]
''. Given that the ability of antigen presenting cells to activate naïve T cells is vital to initiating the adaptive immune response, the presence of corticosteroids could impair this process. Even though memory T and B cells may start forming early in the response, they continue to differentiate and proliferate over several weeks [6,7,8]. Corticosteroids may also affect memory cells once they are generated. Although it is possible that some memory cells are more resistant to such insult, recent data suggest that CD8+ T cell memory may be more sensitive [9,10]. Importantly, these
effects are dependent on corticosteroid half-life. For example, if the half-life of a long-acting
corticosteroid is (at most) three days, its levels will be reduced 1000-fold, four weeks after administration (and close to 100-fold, two to three weeks after). This will reduce the effects on
immune response dramatically. Table 1 shows the duration of action of various corticosteroids
used in clinical settings [11]
I don't think there's any issue of what to do. What you've printed here is theoretical. But let's look at something concrete, which is, everyone who has gotten into the ICU with severe covid has had the same steroid you took. They didn't all die. Most of them didn't die. Most of them having gotten to that point got vaccinated, and I'm guessing if that steroid, given multiple times to those patients unlike you who only had the one shot, rendered the vaccine ineffective in a measurable way, meaning measuring antibodies and T Cell function, we'd know by now. But okay, you had the shot, but not at the same time you had the vax. Your body had already learned how to recognize the spike protein. And if you wait the time recommended before getting your booster, the effect will be gone and the booster will give you added immunity. So again, you don't have an issue, you know more than most of us that you should get the booster when it's your time to do so. Don't overthink it. In the meantime, if you're worried, remember, we all had a lot of this pandemic before the vax existed and most of us wore our masks and distanced and came through it. Those who didn't, didn't do so well. You'll be fine. Peace.
But, let this be a lesson to you and everyone who read this and is something I keep saying to be cautious about and often get a lot of flak for it, but always be cautious when a doc tries to give you medication. There's always a downside so make sure it's necessary to take it and it's the right med for the problem and there isn't a less invasive way to proceed first to see if that works. Look at medication as something great to have because life was a whole lot harder before we had them, but that they don't work as well as advertised, nothing works as well as advertising makes it seem, they have more problems than most of us realize, and so just make sure of what you're taking and why. It's a good lesson for us all. When you need it, you take it, like the vax, and you live with it, and when you don't, you don't until you do.
ofc, I am planning in a week time after steroid injection to get the booster.
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