When I am having a bout of Mania, it has been noticed by friends, family, doctors and myself that my pupils constrict, the doctors never mentioned that this is an issue, but I have always wondered why. I am currently not on any medication (was deemed stable enough) and I also have ADHD and Crohn's so it might be related to one of those issues. The reason I think it is related to Bipolar is the constriction only occurs when I am manic