Dear Debi7704: Microcalcifications are small calcium deposits found within the breast tissue. Microcalcifications in and of themselves are not a condition that would become cancerous however they can be a sign of a problem that may need further investigation based on their appearance on a mammogram. For instance microcalcifications that are more scattered are probably due to a benign (non-cancerous) cause, a “cluster” of microcalcifications may increase concern that there may be an underlying tumor, thus the recommendation for further testing which may include a biopsy. The appearance of a new area of microcalcifications is not uncommon and each occurrence of a new area of microcalcifications would be evaluated separately.