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Jul 28, 2009 - 5 comments

i am so tired of waking each day with a list a mile long of chores to accomplish...and being so overwhelmed with where on earth to start, the day is almost over with!  what the hell is going on?  i have always been energetic and a hard worker...and now i feel like a's miserable and embarrassing.  every evening mike comes home from work...i hear the door open and a slight panic runs through me...did i do enough today?  do i look ok or like a slob?  why isn't dinner ready??? my poor husband...i suck as a wife...did i do enough with the kids today?  i am doubting every single thing i do and bashing myself for every single thing i have NOT done...i was always proud of my life and how i raised the kids, ran the household  and did a wonderful job as mikes wife...and now it's only shame...i just want to know why...why is this my life and more importantly WHY can't i change it when i want to sooooooo badly?????

Ever experience Seratonin Syndrome?

Jul 23, 2009 - 0 comments

maoi interation


Adverse Drug Reactions

I was in a hypo/mixed  state for a few weeks and just wanted to sleep soooooooo very much...none of my meds were working so I started taking Tylenol P.m. with my night time first 4...then up to 6 then by the end of the week 8.  It never made me sleep...instead...I was in a horrible state...I never paid much mind to my 'WARNINGS' on the meds...yep (STUPID ME) it goes:

Serotonin syndrome is a potentially life-threatening adverse drug reaction that may occur following therapeutic drug use, inadvertent interactions between drugs, overdose of particular drugs, or the recreational use of certain drugs. Serotonin syndrome is not an idiosyncratic drug reaction; it is a predictable consequence of excess serotonergic activity at central nervous system (CNS) and peripheral serotonin receptors. For this reason, some experts strongly prefer the terms serotonin toxicity or serotonin toxidrome because these more accurately reflect the fact that it is a form of poisoning. It may also be called serotonin storm, hyperserotonemia, or serotonergic syndrome.

The excess serotonin activity produces a spectrum of specific symptoms including cognitive, autonomic, and somatic effects. The symptoms may range from barely perceptible to fatal. Numerous drugs and drug combinations have been reported to produce serotonin syndrome. Diagnosis of serotonin syndrome includes observing the symptoms produced and a thorough investigation of the patient's history. The syndrome has a characteristic picture but can be mistaken for other illnesses in some patients, particularly those with neuroleptic malignant syndrome. No laboratory tests can currently confirm the diagnosis.

Treatment consists of discontinuing medications which may contribute and in moderate to severe cases administering a serotonin antagonist. An important adjunct treatment includes controlling agitation with benzodiazepine sedation.

Signs and Symptoms

Symptom onset is usually rapid, often occurring within minutes. Serotonin syndrome encompasses a wide range of clinical findings. Mild symptoms may only consist of increased heart rate, shivering, sweating, dilated pupils, myoclonus (intermittent tremor or twitching), as well as overresponsive reflexes.Moderate intoxication includes additional abnormalities such as hyperactive bowel sounds, high blood pressure and hyperthermia; a temperature as high as 40 °C (104 °F) is common in moderate intoxication. The overactive reflexes and clonus in moderate cases may be greater in the lower limbs than in the upper limbs. Mental status changes include hypervigilance and agitation.Severe symptoms include severe increases in heart rate and blood pressure that may lead to shock. Severe cases often have agitated delirium as well as muscular rigidity and high muscular tension. Temperature may rise to above 41.1 °C (106.0 °F) in life-threatening cases. Other abnormalities include metabolic acidosis, rhabdomyolysis, seizures, renal failure, and disseminated intravascular coagulation; these effects usually arise as a consequence of hyperthermia

The symptoms are often described as a clinical triad of abnormalities
Cognitive effects: mental confusion, hypomania, hallucinations, agitation, headache, coma
Autonomic effects: shivering, sweating, hyperthermia, hypertension, tachycardia, nausea, diarrhea.
Somatic effects: myoclonus (muscle twitching), hyperreflexia (manifested by clonus), tremor.

To Lithium or NOT to Lithium...that is the ?

Jul 23, 2009 - 3 comments i am just OVER the damn side effects...i MEAN       O V E R      I T !!!!!
The weight gain, hair loss, foggy head, acne (at my age is absolutely embarrassing), dry skin and bloat...I mean REALLY...what the hell good is this **** anyway?  I know I's the supposed "Gold Standard' right...well not my GOLD STANDARD!!!  Of course I can't mention the fact that I stopped Lithium about a week ago to any family or friends because they will all be  pissed off (rightfully so I suppose)...BUT I NEED A BREAK!  I just feel so out of control taking these meds...I have no freakin clue who I am anymore...where is the line between the Michelle I know and this CrAzY Bipolar????  Bear with me I am just venting...that's what this is here for right???  I sometimes ask myself..."Maybe they just misdiagnosed you...(don't laugh out there ppl...I know what you are thinking).  This is not the life I had envisioned for myself...I don't want to be on a pity party...I want to have my life back...I KNOW it could be worse...I am blessed by much, and even at the end of this vent I know feel kinda bad...for BITCHING...sorry I am all over the damn place...

MAOI Side Effects that can go unnoticed...

Jul 23, 2009 - 0 comments



Bipolar Depression


major depressive disorder


seratonin syndrome

I learned the VERY hard way and suffered Seratonin Syndrome a few weeks back...maybe this can help others from taking these warnings so lightly and mixing OTC drugs with the brain meds...
(I use Parnate)

Side effects of monoamine oxidase inhibitors (MAOIs)

All antidepressants can cause side effects. Your doctor can help you find the drug that suits you best.

Treatment with an antidepressant might make you think more about suicide, especially when you first start taking it.
U.S. Food and Drug Administration.
Antidepressant use in children, adolescents and adults.
May 2007. Available at (accessed on 24 March 2009).
      1 Young people are most at risk, especially anyone under 18.

A big problem with monoamine oxidase inhibitors (MAOIs), such as phenelzine (Nardil) and tranylcypromine (Parnate), is that they react with lots of other medications, foods and alcoholic drinks.

If you take an MAOI, eating foods containing the natural chemical tyramine (such as aged cheese) can dangerously raise your
     blood pressure
Blood pressure is the amount of force exerted by the blood on the walls of the vessels that carry it. You can think of it like the water pressure in your home: the more pressure you have, the faster and more forcefully the water flows out of the shower. Blood pressure is measured in millimeters of mercury (written as mm Hg). When your blood pressure is taken, the measurement is given as two numbers, for example 120/80 mm Hg. The first, higher, number is called the systolic pressure, and the second, lower, number is the diastolic pressure. The systolic number is the highest pressure that occurs while the heart is pushing blood into the arteries. The diastolic number is the lowest pressure that happens when the heart is relaxing and is not pushing the blood.       blood pressure.      Source:
British National Formulary.
Monoamine-oxidase inhibitors (MAOIs).
Section 4.3.2. British Medical Association and Royal Pharmaceutical Society of Great Britain. Also available at (accessed 24 March 2009).
      2 The first sign of very high blood pressure is usually a throbbing headache. If this happens, see your doctor right away. People taking these drugs have to be careful about what they eat.

If you take an MAOI, you should avoid:
British National Formulary.
Monoamine-oxidase inhibitors (MAOIs).
Section 4.3.2. British Medical Association and Royal Pharmaceutical Society of Great Britain. Also available at (accessed 24 March 2009).

Meat extracts or yeast extracts
Broad beans, especially the pods
Pickled herring
Cough, cold and flu remedies containing a decongestant
Alcoholic drinks (even low-alcohol drinks such as non-alcoholic beer)
Aged cheeses (such as cheddar, Parmesan, blue)
Smoked or pickled meat, poultry or fish
Fermented sausage (such as bologna, pepperoni, salami)
Overripe fruit
Large amounts of coffee, tea, cola, chocolate or other items containing caffeine.
Make sure to ask your doctor for a full list of foods, drinks and medications to avoid.

MAOIs also react dangerously with most other antidepressants.
British National Formulary.
Monoamine-oxidase inhibitors (MAOIs).
Section 4.3.2. British Medical Association and Royal Pharmaceutical Society of Great Britain. Also available at (accessed 24 March 2009).
      2 The combination of tranylcypromine (Parnate) with clomipramine (Anafranil) is particularly dangerous.      Source:
British National Formulary.
Monoamine-oxidase inhibitors.
Section 4.3.2. September 2007. BNF 54. British Medical Association and the Royal Pharmaceutical Society of Great Britain. Also available at (accessed on 24 March 2009).
      3 Clomipramine is a tricyclic antidepressant.

If you stop taking an MAOI, you should not start taking another antidepressant for two or three weeks.

Common side effects of MAOIs
In studies, the most common side effects reported by people taking MAOIs were:      Source:
Thase ME, Trivedi MH, Rush AJ.
MAOIs in the contemporary treatment of depression.
Neuropsychopharmacology. 1995; 12: 185-219.

     low blood pressure
If your blood pressure is about 100/60 or less, your doctor may say that you have low blood pressure. Low blood pressure is usually not a problem unless it becomes too low to push blood to your brain and the rest of the body. If you have low blood pressure, you may sometimes feel dizzy when you stand up. To find out what these numbers mean, see blood pressure.       Low blood pressure, causing faintness
Blurred vision
Goose bumps
Difficulty sleeping
Problems with sex, including being unable to have an orgasm.