Jul 09, 2008
The use of tramadol over more than 1 year, as in our patient, eventually may have resulted in a build up of the active metabolite M1 in peripheral tissue sites such as skin, muscles, fat and connecting tissue, which do not participate in the mediation of effects but in fact may act as a reservoir. This assumption is corroborated by forensic data where tramadol was involved in an overdose fatality (Moore et al., 1999), suggesting that a build-up of tramadol and/or its metabolite within peripheral tissues following long-term use does occur.
Here's me with my mouth open; aghast and horrified!
This is Day 20 off Tramadol. I woke up with horrible intestinal pain and managed to get back to sleep. Thank goodness or I would be fried the rest of the day.
I've also read that Tradamol CAUSES neuropathy as a side effect!
*insert scream here*
This message today from an understanding friend;
"I think with the bad stuff you read about tramadol, you're just getting confirmation that the gruelling withdrawal is worth it - it ***** when there's no undoing the past and the present is painful, but at least it means the future will be better, you know? I'm sure there will be a giant class-action suit if there's not now, as well there should be."
Thank GOD for good friends who understand
I look bad today. Particularly bad.
Ok ... onward. Day 20 is not so good, but it could turn around at any minute. This has been my experience and I am stickin' to it!
I also found THIS;
Tramadol Hydrochloride orally disintegrating tablets is a centrally acting analgesic in an orally disintegrating formulation using a tablet formulation base. The chemical name for tramadol hydrochloride is (±) cis -2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride. Its structural formula is:
Tramadol Hydrochloride is supplied as orally disintegrating tablets containing 50 mg of tramadol hydrochloride for oral administration.
Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. The n-octanol/water log partition coefficient (logP) is 1.35 at pH 7.
The tablets are white in color and contain the inactive ingredients aspartame, copovidone, crospovidone, ethylcellulose, magnesium stearate, mannitol, mint flavor, and silicon dioxide.
There is ASPARTAME in it? I have a huge adverse reaction to aspartame. I can't even believe that is in there. *mumble mumble mumble mumble*