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The effects of NSAID's on ovulation

Apr 28, 2012 - 15 comments






So I had heard of this and in theory it made sense... Ovulation is a process of inflammation, therefore taking an anti-inflammatory (pain reliever) such as ibuprofen can decrease or halt the size of a follicle when it's getting close to rupturing (collapse=ovulation).

Well on Wednesday I got a full blown positive and started feeling O pains. By thursday my OPK was back to negative (which always indicates ovulation is imminent) and those pains had increased so bad, I mean BAD!! I knew I was about to ovulate any moment and probably more than one egg! Unfortunately I was in the middle of finishing up floral arrangements for my aunts funeral (the following day) so I needed to be able to function! I reluctantly took a mega dose (800 mg) of Advil and boy, It REALLY helped!! Problem is the next morning I woke up without my typical temp shift... It did raise but not enough. I thought hmmm... maybe it'll take one more day or I'm having a slow rise?? Until later that evening after i was home and in bed, I felt those darn UNMISTAKABLE ovulation pains returning!! I woke this morning to an even lower temp so I took an OPK and lo and behold POSITIVE AGAIN!!


I have never experienced anything like this before. My cycles are like clockwork unless I'm on a medicated cycle, then it speeds everything up. But even on medicated cycles, I have never experienced delayed ovulation!

So I just wanted to put that out there in case anyone was ever in or finds themselves in a similar situation. Next time I'll use tylenol LOL.

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647911 tn?1373314647
by nic374, Apr 28, 2012
yes this is very ture, nsaids will mess with ovulation, another reason why is because since it is a anti inflammorty it also cause ur natural fluids to dry up, so u might expreience dry eye, mouth, skin etc, however u can combat that with lots of drinking water, it was also dry up ur cm, so u wont experince the ew type, Now I think this is more uncommon then common messing up the ovulation where it screws with the follice. but it will happen if u take it every day and in mega, mega dose amount, I think its the acutally drying up of natural fluids that cause infertility issues in nsaids user more than not ovulating. You can also have a postive on a OPK but not ovulate, unless like u said u get a temp shift/ It does mess with the gland in ur brain for reproduction, and nsaids have that side effect of drying ever thing up.

1351078 tn?1416313146
by retta483, Apr 28, 2012
yeah when I did a medicated cycle they told me no ib profein  which I could have been screwing with my ovulation for months because I normally take ib profein all month . I dont take it now after knowing that . well hopefully the eggie will come out now and make a baby 4 you <3

1571146 tn?1399909692
by Moma_Cher, Apr 28, 2012
Thanks ladies. I just hope I do actually ovulate, and soon!! I'm not really in the mood for marathon baby dancing lol

Retta, I actually read it can interfere with implantation too... So I wonder if that was having any impact on all those chemicals you had??

Nic- I didn't know it dried you up as well... Thanks for the info! I stop taking my allergy pills at like cd5 because I know sudafed will do the same! It ***** cos my allergies are NUTS lately!!!

377493 tn?1356502149
by adgal, Apr 28, 2012
Well you learn something new everyday.  It makes perfect sense when I read about it, but that would never even have occured to me.  Thanks for the info!

I sure hope you ovulate soon and that this is your month!!

1293683 tn?1334019210
by tones99, Apr 29, 2012
I discovered this when I studied nutrition years ago and promptly stopped taking my weekly ibuprofen .. it also hardens the follicle so it makes it harder for the egg to be released and when it eventually does, it has over-matured .. things that no drug company ever bothers to tell you!

It should come with a warning for those ttc as most people wouldn't know any of this

moma cher .. it does also interfere with implantation too as it irritates the uterus walls .. all round bad guy for us girls!

647911 tn?1373314647
by nic374, Apr 29, 2012
moma cher: yes Im a ibprofen lover <3, so I know much about it and fertility, also lose dose asprin is not in the same family as NSAIDs but it can cause the same effects, The only safe thing is the acementphiem spelled that wrong, Nsaids will not store in ur body like anti depressents and some other meds it has a short half life 4-6hrs I think, u will process it thru ur kidneys  and will expell it when u pee, drink lots of water when a meds drying up all ur natural fluids that really will go a long way in helping ur body, good luck :)

377493 tn?1356502149
by adgal, Apr 29, 2012
Nic, curious about the low dose asprin.  My RE has me on a low dose asprin per day.  He said it's a common thing to prescribe for those of us that have experienced multiple miscarriage.  Now I'm worrying....could it actually be having a negative affect?

1571146 tn?1399909692
by Moma_Cher, Apr 29, 2012
I was wondering the same since I sometimes take low dose aspirin? I thought it helped with implantation?

1571146 tn?1399909692
by Moma_Cher, Apr 29, 2012
Adgal, I found this....

Aspirin is made from the chemical acetylsalicylic acid, which reduces pain and swelling by inhibiting the action of Cox-2 enzymes in your body, which produce prostaglandins, the hormones that cause muscular constriction, fever, and inflammation.

Scientists believe that aspirin may help women who experience recurrent spontaneous abortions (miscarriages) conceive and carry a baby to term. Some of these women have very high levels of antiphospholipid antibodies, which cause blood platelets to stick together and the blood to thicken. This can increase the risk of developing dangerous blood clots which, if they develop around the placenta, can deprive the baby of oxygen and nutrients, resulting in a miscarriage. These antibodies may also interfere with the embryo's ability to attach to the uterine wall.

When low-dose aspirin, also called baby aspirin, is given to these women, their platelets become less sticky, their blood circulates more smoothly, and precious oxygen and nutrients are delivered to the placenta. It may also help the embryo attach and grow on the uterine wall.

A recent study conducted in Argentina and published in Fertility and Sterility demonstrated the effectiveness of low-dose aspirin with women who had experienced multiple miscarriages and who were undergoing in vitro fertilization (IVF). The study compared two groups of 149 women. One group took a daily dose of aspirin along with their IVF medication to stimulate their ovaries, while the other group took just the IVF drugs. Forty-five percent of the women who took the aspirin became pregnant, but only 28 percent of the other group conceived. The researchers also found that the women taking aspirin produced more eggs than the other group and they were able to retrieve an average of 16.2 eggs from them, compared with just 8.6 eggs from the non-aspirin group.

So I guess it's probably a good thing in low doses.... Agree?

377493 tn?1356502149
by adgal, Apr 29, 2012
Sure sounds like it to me. Thanks for that info!

I know in my case the timing of my miscarriages is more often then not right around the time the placenta is forming.    I also had placenta trouble when I had my successful pregnancy - it stopped functioning around 34 weeks (they think, it wasn't caught until 38 weeks) and so Ryder was an IUGR baby.  I had bleeding throughout my pregnancy too.  Initially due to a hematomma, but in third trimester they believe it was due to a small tear found.  

Based on all of this, my RE really thinks (although this is not a proven theory) that for some reason my body struggles with building a healthy placenta.  They have tested the tissue in at least 4 of my losses, and no chromosomnal abnormality was ever found.  Interestingly, my mother also suffered from multiple miscarriage..she had 7 (I've now had 8) and she was in her 20's and very early 30's.  So my RE does believe there is a genetic component here as well.  Tests haven't shown anything, but he does believe that the daily low dose asprin may help.  

I always start out strong..HCG levels doubling as they should, formation of sac, but it's always around the 6 week mark or so that things begin to go sideways.  And everyone here that knows me knows I am incredibly fertile..I conceive without any issue at all, even into my 40's.  So my RE says that although the standard theory should be "old eggs", if that were the case I shouldn't be conceiving as easily as I do.

Anyway, didn't mean to hijack your journal, but obviously what you have written above is of huge interest to me and I have no doubt will help someone else as well.  This is a really good journal Momma Cher.  Maybe it will also help other 40+'s in conceiving and carrying.  

1571146 tn?1399909692
by Moma_Cher, Apr 29, 2012
Not hijacked at all! You have added to the discussion, which is awesome!

I hope we all reach our goals soon :-)

377493 tn?1356502149
by adgal, Apr 29, 2012
From your lips to God's ears my friend.  Everytime I read of another awesome women getting her bfp it's almost as exciting as getting my own.  That's why I'm always stalking profile

1742167 tn?1436471720
by heather727, Apr 30, 2012
I really feel (even though there's no way to know for sure) that my miscarriage in 2010 was caused by my taking ibuprofine between ovulation and my missed period.  My DH and I weren't trying, so I didn't think anything of taking Advil a couple times of day for about a week right around when implantation was happening.  I stopped taking it as soon as I got my BFP but I had spotting around 6 weeks and then fully miscarried at 8 weeks.  So once I started officially TTC, I stopped taking it all together.  It just wasn't worth the risk!

Avatar universal
by lmolyna, Sep 22, 2013
i always notice a 2 days delayance on my cycle when ever i take ibuprofen meaning i hav a two days delayed lmolyna,26

Avatar universal
by Zkin, Dec 05, 2014
Ibuprofen is also used in fertility treatment to stop/prevent you ovulating too quickly before egg retrieval. In my case  my doctor gave me  to take  it from  cd10 (1 dose 400mg) , cd11-12 :200mg x3,  and cd13 one last dose in the morning. I got HCG shot at midnight on cd12 and then having  IUI done at 1315 hrs on cd14.

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