Reyataz

Generic Name: atazanavir
Other Brand Names: atazanavir

What is atazanavir (oral)?

Atazanavir is an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Atazanavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

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Uses Side Effects Precautions Interactions Overdose
What should I discuss with my healthcare provider before taking atazanavir (oral)?

Do not take this medication if you are allergic to atazanavir.

Do not take atazanavir with cisapride (Propulsid), pimozide (Orap), midazolam (Versed), triazolam (Halcion), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

These drugs can cause life-threatening side effects if you use them while you are taking atazanavir.

Before taking atazanavir, tell your doctor if you are allergic to any drugs, or if you have:

  • liver disease;

  • kidney disease or a history of kidney stones;

  • diabetes;

  • a bleeding disorder such as hemophilia;

  • high cholesterol or triglycerides;

  • a heart condition called "AV block”; or

  • if you have ever used a protease inhibitor in the past.

If you have any of these conditions, you may not be able to use atazanavir, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby, but HIV can be passed to the baby if the mother is not properly treated during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Take all of your HIV medicines as directed to control your infection while you are pregnant.

Your name may need to be listed on an antiviral pregnancy registry when you start using this medication.

Taking atazanavir while using birth control pills or patches can make the atazanavir less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking atazanavir

You should not breast-feed while you are using atazanavir. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk.

Do not give this medication to a child younger than 3 months old.

How should I take atazanavir (oral)?

Take atazanavir exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Take atazanavir with a full glass (8 ounces) of water.

Atazanavir should be taken with food. Swallow the capsule whole.

It is important to use atazanavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

Store atazanavir at room temperature away from moisture and heat.

What happens if I miss a dose of atazanavir (oral)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Where can I get more information about atazanavir (oral)?
Your pharmacist has information about atazanavir (oral) written for health professionals that you may read.
What are the possible side effects of atazanavir (oral)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking atazanavir and call your doctor at once if you have any of these serious side effects:

  • increased urination or extreme thirst;

  • severe pain in your side or lower back, painful urination, blood in your urine;

  • easy bruising or bleeding;

  • signs of a new infection, such as fever or chills, cough, or flu symptoms; or

  • jaundice (yellowing of the skin or eyes).

Keep taking the medication and talk with your doctor if you have any of these less serious side effects:

  • nausea, vomiting, diarrhea, stomach pain;

  • numbness or tingling, especially around your mouth;

  • joint pain;

  • headache, mood changes; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about atazanavir (oral)?

Do not take atazanavir with cisapride (Propulsid), pimozide (Orap), midazolam (Versed), triazolam (Halcion), or an ergot medicine such as Ergomar, Cafergot, Wigraine, D.H.E. 45, Migranal, Methergine, and others.

These drugs can cause life-threatening side effects if you use them while you are taking atazanavir.

There are many other medicines that can interact with atazanavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

Taking atazanavir will not prevent you from passing HIV to other people through unprotected sex or sharing of needles. Talk with your doctor about safe methods of preventing HIV transmission during sex, such as using a condom and spermicide. Sharing drug or medicine needles is never safe, even for a healthy person.

What should I avoid while taking atazanavir (oral)?

Avoid using antacids within 1 hour before or 2 hours after you take atazanavir.

If you also take didanosine, take it 1 hour before or 2 hours after you take atazanavir.

Taking atazanavir will not prevent you from passing HIV to other people through unprotected sex or sharing of needles. Talk with your doctor about safe methods of preventing HIV transmission during sex, such as using a condom and spermicide. Sharing drug or medicine needles is never safe, even for a healthy person.

What other drugs will affect atazanavir (oral)?

Atazanavir should not be taken together with ritonavir (Norvir) if you are also using a steroid medicine called fluticasone (Advair, Flonase, Flovent). Ask your doctor about taking a different HIV medication, or using another treatment for your allergic condition.

Before taking atazanavir, tell your doctor if you are using:

  • bepridil (Vascor);

  • digoxin (digitalis, Lanoxin, Lanoxicaps);

  • St. John’s wort;

  • antibiotics such as clarithromycin (Biaxin), itraconazole (Sporanox), ketoconazole (Nizoral), rifabutin (Mycobutin), or rifampin (Rifadin, Rimactane, Rifater);

  • antidepressants such as amitriptyline (Elavil, Etrafon), imipramine (Janimine, Tofranil), trazodone (Desyrel), and others;

  • a blood thinner such as warfarin (Coumadin);

  • a calcium channel blocker such as amlodipine (Caduet, Lotrel, Norvasc), diltiazem (Tiazac, Cartia, Dilacor), felodipine (Plendil), nifedipine (Procardia, Adalat), or verapamil (Calan, Covera, Isoptin, Verelan);

  • cholesterol-lowering medicine such as atorvastatin (Lipitor), lovastatin (Mevacor, Altocor), pravastatin (Pravachol), or simvastatin (Zocor);

  • drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);

  • heart rhythm medications such as amiodarone (Cordarone) or quinidine (Quinaglute, Quinidex);

  • insulin or diabetes medication you take by mouth;

  • medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);

  • other HIV /AIDS medicine such as efavirenz (Sustiva), indinavir (Crixivan), ritonavir (Norvir), or tenofovir (Viread); or

  • stomach acid reducers such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), omeprazole (Prilosec), or ranitidine (Zantac).

If you are using any of these drugs, you may not be able to take atazanavir, or you may need dosage adjustments or special tests during treatment.

There are many other medicines that can interact with atazanavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

What happens if I have an overdose of atazanavir (oral)?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an atazanavir overdose may include jaundice (yellowing of the skin or eyes).

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Content provided by Multum - Last Updated 2/11/2008