Bone and liver metastasis

[tere2009]

My sister 42 years, has got after 7 years metastasis from her breast cancer on bones and liver. She has 5 metastasis in the liver and in the hip. She is Brca1 carrier and the tumor is HER2 negative. She is on a palliative treatment and has passed three cycles of chemotherapy: docetaxel plus avastin (each cycle after 21 days). Apart from that she has got 10X radiation (max dose) on the right hip. We have just made the control of the disease and the largest tumor in the lever has been reduced from 4.9 to 4.2 mm. The pain in the hip has become more or less uncontrolable and she is being treated with max dose morphin plus others. No evidences of fracture but an MRI will be done. I wonder if the decreased in the lesions in the liver is considerable or not and if she should consider changing treatment. The gammography coloured the hip very intensily but it has only passed a month since the radiotherapy. Noone has an explanation for the intense pain in the hip (she can not walk and only lay in bed the whole day). PLease help! She is suffering enormously

[tere2009]

Thank you for your answer. So if you think that the reduction is not much which therapy do you think it could be more appropriate? I have read that cisplatin is recommended for Brca1 carriers. In that case in combination with what? Could the tumor also be resistant to cisplatin?
The pain in the hip was better during radiotherapy but one week later became very intense. Can the radiotherapy activate tumor growth in the bone in her case? Can the tumor be totally resistant to the therapy? The markers though diminished considerably
I appreciate your help
Thanks!

[japdip]

The decision about stopping treatment should be discussed with the Oncologist who knows all the particulars of her case. The pain in the hip is due to the cancer or damage that it has caused to the bone. If you are not happy with the current treatment plan then by all means get a second opinion from an outside Oncologist. The decrease in the liver mets isn't all that much.  Regards ....