Is there a link between breast cancer & crohn's disease? My husband's grandmother, mother & 2 aunts died of breast cancer - the 4th daughter was clear. My husband & my oldest daughter have crohn's disease. Hope this makes sense to you.
Hi - I have Crohn's (dx 1970 when I was 24 yrs old) and got invasive ductal cancer, with spread to my lymph nodes, in 2003. I have wondered if the two diseases are somehow connected, although neither my older sister nor late mother had either disease. I have asked this question to both my gastroenterologist and oncologist and they said not, but this was 5 yrs ago and perhaps as technology moves on, researchers are finding an oblique connection, particularly through genetic studies. I have read that both Crohn's and breast cancer are prevalent in the Ashkenazi Jewish population that came from Eastern Europe. As far as my sister and I know, my maternal grandfather could have been Jewish, but the synagogue in the town where he grew up was bombed in WW11 and there are no records. Researchers have recently found a gene, NOD2, that is over expressed in Crohn's so the condition could be due to hereditary factors. I have not been tested for this, as I have known Crohn's, neither have I been tested for the BRCA1 and BRCA2 breast cancer genes, since none of my immediate family have/had breast cancer. I personally believe there is a genetic link between my two diseases, but have no proof.
Thank you Liz. Apparently the breast cancer gene can mutate to Crohn's. We wondered why 3 sisters & Grandmother had breast cancer & the other sister did not. However lost contact with this aunt & really don't know if she or her children had Crohn's.
Thanks for your response. I have asked my gastro and Oncologist, but they both say there is no link. I don't believe them. It is interesting that when I was dx with Crohn's, neither my gastro nor Oncologist had ever dealt with a patient with concurrent disease.
I emailed every major hospital in the US I could think of (Mayo Clinic, MD Anderson, John Hopkins etc. the only IBD hospital in England, and they all replied and said they have never had a patient with concurrent diseases. Since then, some 5 yrs ago, I have met a number of women via the internet, with both diseases. I do believe there is a link in our genetic make-up. Time will tell. I unfortunately, or perhaps fortunately, don't have children as I was born with bi-corunate wombs. At least I don't leave children with what I believe are genetic problems.
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