I am a 48 year old female who had a mastectomy in May due to DCIS. Was advised to take tamoxifen, but haven't started to take as of yet. Am worried about all of the side effects and am wondering if it will be helful to me since I had a hysterectomy in 1996. Have talked to several women who had same surgery years ago and were never placed on hormone therapy and are doing fine. Would really rather not take Tamoxifen if possible. Any advice?
Ductal Carcinoma In Situ (DCIS) is a noninvasive carcinoma. The cancer cells are confined to the ductal structures. DCIS can be treated by: excision (lumpectomy or breast conserving surgery) plus radiotherapy to the breast, excision alone, or mastectomy. Tamoxifen may or may not be given after surgery. There is currently no consensus regarding the optimal treatment of DCIS.
There was a clinical trial called NSABP B-24 where Tamoxifen was given after lumpectomy and radiotherapy which showed a decrease in ipsilateral local recurrence, contralateral breast cancer, and all breast cancer events. Here is the link of the said clinical trial: http://www.breastcancerupdate.com/oncology_leader/morrow/nsabp_role_tamoxifen.html#nsabpb24roletamox
However, in another trial called UK DCIS trial, there was no statistically significant difference in the rate of ipsilateral local recurrence, contralateral breast cancer, and all breast cancer events with the addition of tamoxifen after surgery and radiation therapy.
You need to discuss with your oncologist your treatment options, weighing the risks and benefits of treatment.
Copyright 1994-2016 MedHelp International. All rights reserved.
MedHelp is a division of Aptus Health.
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.