I'll try to be brief. 46, female, divorced with one child, stressful job and not alot of time. Had mitral valve repair surgery one year ago (4/2001). Home three months and had to go back to work. Was still feeling depressed and full of anxiety. My Dr. tried putting me on Celexa. I could not handle it & had to stop taking it. After four days of taking 1/2 the lowest dosage, I was feeling lethargic, more anxious and extremely strange. I tried at that point to handle it without meds. My whole life has been somewhat ups and downs, could always handle it without strong medication, but no longer feel that I can handle on my own. Something happened recently that has put me over the edge. I am severly depressed. My doctor tried Zoloft this time, 25mg. to start, a day. Again, it made me feel very wierd and I swear, more depressed. I stopped taking it after three days. I do not know what is left. If two SSRI's react that way with me, I am afraid they all will, and they are all so powerful. Yet, I am deeply depressed. I cannot get in to see a pshchriatrist (3 referrals told me they could see me in six weeks!) I have heard about wellbutrin. Does that act differently? I even tried Ativan and Xanax, but it does not help. I also heard about SAME but that is herbal. I definately need something. Where can I turn. I am in therapy, but I cannot bounce back as easily as I did prior to surgery. Could this still be the effects of open-heart surgery one year later? I need SOMETHING that will get me out of this deep depression.