Feeling depressed and tired can be normal. I would have concerns because you mention 'two serious bouts'. This is something you need to monitor.
I sometimes have a desire to have a baby/ babies. I am not in a relationship but sometimes I feel I could be a total **** just to achieve this (although this goes against all my values and beliefs).
I think it can be both biological and psychological.
I don't know if this helps much.
J
When you off these medications, you begin to feel your own feelings again...and that can be very good...sounds like you are reexperiencing the suppressed feeling that happens after a hysterectomy...some real life, but tempoary, depression about the loss of what might have been, but can't be. Process it, don't panic, just feel and think and sort things out.