Digestive Disorders / Gastroenterology Expert Forum
Ms. twiceluckymama
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Ms. twiceluckymama

I recently had an employer-sponsered health screening in which I had mildly elevated GGT, uric acid, and cholesterol.  I am 34, an ovo-lacto vegetarian, breastfeeding, and at the time of the test, was taking three 500mg fish oil capsuls and an 81mg baby aspirin daily, along with b-12, b6, and folate.  I abstain from alcohol while pregnant and lactating; I only drink 1-2 times per year when not. I tested positive for four antiphospholipid antibodies, including anticardiolipin, antiphosphatidylserine, antiphosphatidylinositol, and one other (negative for antiphosphatidylethanolamine), 1.5 years ago (and was found to be heterozygous for MTHFR and Leiden factor V) after having two subsequent first-trimester miscarriages (each followed a pesticide (type II pyrethroid) exposure by 9-10 days).  I have read that prolactin (breastfeeding) can cause elevated cholesterol, and that aspirin can cause elevated uric acid levels. Can my elevated GGT  levels be related to antiphospholipid antibodies, and if so, what does that elevation with APA mean?  Am I right to discount the uric acid and cholesterol impacts, or, given the existing health conditions, are there things I should watch for in the future?  I notice that I feel mildly sick and have quicker digestion than normal when I eat a very fatty meal, rather than my usual fare.  
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This is not really a GI question and some of these issues are outside the scope of my knowledge.

There are some studies in rats that an elevated prolactin level can affect cholesterol.  However, in cases of breastfeeding, the rise in levels are normally transient and go back down.  Persistent elevations in prolactin levels should be investigated further.  

Regarding the cholesterol, normal measures like dietary and lifestyle changes should be done as well to lower the levels.

Although possible, I am not aware of a significant increase in uric acid levels with aspirin.

It is true that the APA levels may also be associated with a rise in GGT.

Treatment of APA may involve anticoagulants like heparin or warfarin.  Marked surveillance for thrombotic events should be done as well.  

Followup with your personal physician is essential.

This answer is not intended as and does not substitute for medical advice - the information presented is for patients education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
www.kevinmd.com
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