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SGPT and related abdominal symptoms
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SGPT and related abdominal symptoms

I am a 29 year old married male who is 6 ft tall and 175 lbs.  I drink almost no alcohol, have never smoked and have been tested negative for hepatitis. In June of 1995, I was asked to donate blood for a relative (with my same blood type) who was having surgery.  When I went in to donate, I was rejected as a donor because my ALT was 65 (the limit for males was 59).  I immediately made an appointment with my GP who ordered SGPT and SGOT tests resulting in 83 (ref 10-55) and 42 (ref 10-40) respectively (my weight at the time was about 190 lbs).  I was led to believe that since my results were only mildly high, not to worry and I left it at that.  In March of 1999 (weight almost 200 lbs) I started to have frequent heartburn (I had previously only had infrequent heartburn) and made an appointment with my doctor for a full physical two months later this May.  The physical was normal, and routine blood work + diabetes screen was done (I asked that SGPT and SGOT be tested as well).  In addition, an upper GI and abdominal ultrasound was ordered at my insistence due to my symptoms.  The bloodwork came back negative except for the SGPT which was still high at 76.  The upper GI revealed mild GERD and the abdominal ultrasound revealed some fatty liver (all other organs were totally normal).  Immediately following, I was put on Prilosec and started changing my diet and exercise dramatically for the better.  My heartburn has been gone for a few months now (I only had to take the Prilosec for about 1 week at 20 mg and scaled it down to zero alternating days in only three weeks). Also, I used to burp quite often and now almost never do.  At my current weight of 175, virtually all of my GERD symptoms are gone (except one new one which is why I am posting).  I currently have frequent alternating mild abdominal pain in my right lower and left lower abdomen (I believe in my Colon) and occasionally just under my right rib cage.  I can't figure out the exact pattern but the pain virtually never occurs on the left and right side at the same time and it is usually (but not always) relieved after I eat a meal.  My stools have always been totally normal and there is no correlation between my bowel movements and these pains (though I do have frequent flatulence and hear "gas sounds" louder than I think is normal in my abdominal area on quite a frequent basis).  Lifting up my right leg and pulling my knee up to my chest can sometimes relieve the symptoms.  I have tried Metamucil to no effect.  I am still concerned about my high SGPT result (though it hasn't been retested yet, it was 26 ten years ago in 1989).  How common is it for a 6 ft tall 195 lbs. non-drug/no hepatitis/non-drinker to have fatty liver/high SGPT?  Is it possible that there is some link between my lower abdominal symptoms and the SGPT result (i.e. indication of a more serious problem elsewhere in the body, possibly the colon)?  Is it likely that my new weight/exercise regimen has already improved my SGPT/fatty liver?  Is a significant weight lost (from 195 to 175) likely to be disruptive to my colon and/or to have totally cured my GERD?

Lastly, the most important question that I have (if you only answer one this would be it) is:
Now that I am almost "totally cured" is it possible that it is the abdominal gas that is causing these pains (perhaps because of an intestinal blockage of some type?)  I am actually feeling them right now as I type this post.  Is there some type of remedy for this gas?  My diet is quite healthy right now (good protein carb ratio, high fiber, no processed flour/potatoes/rice).  I know that there are antigas medicines for the stomach, are there some for the lower GI?  What other diagnostic tests might be valuable for people exhibiting these types of symptoms?

I am incredibly appreciative of any general information that you can offer in this area and have made an exhaustive internet search of these topics and am still a little confused.  Thank you in advance for your reply.
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Avatar_n_tn
Dear Joe,
Congratulations on initiating a very successful life style modification.  It is hard to change personal habits and it seems as if you have been able to make substantial change.

With regard to the SGPT, there are a number of possible causes.  Fatty liver is one of the more frequent explanations for the elevated liver tests, even though individuals may not be much over the desired body weight.  Other causes to consider include hepatitis, autoimmune liver disease and metabolic diseases e.g. hemochromatosis.  These other conditions, except for hepatitis, are relatively rare.  If the liver tests persist and there is anxiety regarding potential causes, we will order the appropriate tests to exclude these conditions mentioned above.  In some instances, a liver biopsy is done for a definitive diagnosis.

There are a number of over-the-counter preparations for gas.  Simethicone containing compounds are often efficacious.  Charcoal preparations are also used but they can cause constipation.  Often, we recommend fiber e.g. metamucil.  Even though there may be an initial surge of gas discomfort, over time the regular soft bowel movements make the gas discomfort resolve.
19 Comments
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Avatar_n_tn
Joe,

The forum has reached it's limit for new questions today.  Since your symptoms seem similiar in many ways to mine, as well as the fact that you seem much more knowledgable than I on this subject, I thought I would ask you questions concerning my condition.

After applying for a new insurance plan, I learned that my SGOT level was 84 and my SGPT level was 56.  I have no idea what these things mean.  Yet, it was enough for me to be turned down for the insurance program.  

I am 6'2"  250 lbs and in my early 30's.  I do not drink alcohol.  However, I do smoke and drink a great deal of coffee.  I also have terrible eatting habits.  I realize these are bad things and am motivated to change my lifestyle.  

However,  the readings from the blood work concern me a great deal.  Also,  I have a frequent pain below my right ribcage.  

Do you have any idea what these things mean?  I can't afford a doctor's appointment right now and any opinions are welcome by me.  I would greatly appreciate your response.  Thank you!
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Avatar_n_tn
I am 29, 6'4", and 165 lbs.  About 3 months ago, I'd been having problems with diarrea (diarrhea).  I had accidents in my sleep, and when I'd go to the bathroom, I would pass clear, watery bowels. I'd taken blood tests and stool specimens, but my doctor couldn't seem to find a problem.  I beg to differ.  I have been in relatively good heath until this.  I don't drink much, but I do smoke.  My weight has also gone down, and I am very concerned.  Pretty much scared, especially when it comes down to the thought of having to do a colonoscopy.  But if there is a problem (and I believe there is), I need to know. Can you help me find out?
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Avatar_n_tn
Re: James

Before I say anything here, I want to emphasize that I am not a doctor, but am glad to share what I have learned if it can be of help to you.

You might also want to check out: http://www.hepcfoundation.org/disi_bloodtest.html

SGPT (alanine transaminase) and SGOT (aspartate transaminase) are liver enzymes. While they are produced in the liver, elevated levels of these enzymes are often non-specific indicators of problems elsewhere in the body (i.e. you can't be sure of the exact cause of the high value nor can you be certain it is in the liver based on this test alone).

When I first went in to the doctor with my elevated ALT (which I think is the same as SGPT), I was asked if I had recently bruised myself.  Apparently, even mild muscle damage can result in elevated enzyme levels.  Apparently weight lifters (I am not one) often cause damage to their muscles when they do low rep/high weight routines, thereby sometimes effecting their liver enzyme results.

I also got the sense from my doctor that it is not all that unusual for people to have slightly elevated values (look at the normal ranges on the web site I provided).  In my case, to rule out other potential causes, I was tested for Hepatitis, a viral infection which could have been the cause of the elevated enzyme tests.  As I understand it, the reason that I was rejected as a blood donor (and probably you for insurance) was that my liver enzyme test could have been the result of Hepatitis (this was proven to not be the case for me).  I think that you should probably get a Hepatitis test as if you do have Hepatitis, you need to know about it and get treated as it is very serious and is frequently life threatening.  There are three categories of Hepatitis, type A, B, and C.  A person can get type A Hepatitis from ingested food contaminated by fecal matter.  This is an epidemic in third world countries where food handling and sanitary conditions are very poor though I have heard about many cases in the US in my internet research. Type B and C are much more serious (though type A is also very serious) and are often transmitted sexually or by blood transfusion or IV needle sharing.  Hepatitis is much much more contagious than AIDS and infects many more people than AIDS, though one rarely hears about it in the US popular culture.  It is an epidemic is the US, particularly in promiscuous and IV drug using populations.

A second cause of elevated enzyme results comes from liver damage that is the result of drinking.  My understanding is that drinking damages liver cells, though I get the sense that casual alcohol use is not a problem (with regard to the enzyme tests) for most people.

A third cause of elevated enzyme results comes from a condition called fatty liver.  You can learn about this at:
http://www.endowsec.com/pated/ecdlv37.htm
In my case, an abdominal ultrasound revealed this condition.  I still don't know why this was discovered in me, though I have read that you don't have to be grossly overweight to have this condition (this is part of the reason that I decided to start a more healthy lifestyle).  The above web site does a much better job than I could ever do explaining it, but I do understand that heavy drinking can be one of a potential list of causes for this condition.

There are also other causes of high liver enzyme test results which I don't know enough about to comment on, so you are on your  own for these (sorry).

I too had a pain right below my right rib-cage (this is where your liver is located).  I think that at a minimum, you should get screened for Hepatitis (your potential for being infected as revealed by your enzyme tests is probably why your insurance company rejected you).  If you can't afford a doctor, perhaps you could try to find a clinic that could see you and run these tests.

With regard to your diet, I highly recommend a book called Mastering the Zone by Barry Sears Ph.D. This book is the basis for a diet that has swept America (you will be able to find it at ANY bookstore) and has done wonders for me.  It is not a fad, and does not require drastic changes to your diet.  All of the recommendations in the book are strongly supported by clinical data.  You will definitely not be disappointed.  I have not repeated my enzyme tests, but will soon and hope that my weight loss helps to lower them.

I hope that the information that I have written is helpful to you.    I'll check back again later if you need any additional info that I can provide as a lay person.

One last note (and hint):  All blood donation centers run a liver enzyme test prior to donation with a machine that uses a pin ***** blood sample and the machine gives the result in less than a minute.  Perhaps you could find someone to run this test for you.  Be aware however that this test is not as accurate at the one in a blood lab.  Good luck!

----------------------------------------------
For the second poster 6'4", and 165 lbs, see a specialist.  Don't lose sleep about the colonoscopy.  You'll survive, and hopefully will be able to figure out what is going on.  Good luck!
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Avatar_n_tn
Re: James

Before I say anything here, I want to emphasize that I am not a doctor, but am glad to share what I have learned if it can be of help to you.

You might also want to check out: http://www.hepcfoundation.org/disi_bloodtest.html

SGPT (alanine transaminase) and SGOT (aspartate transaminase) are liver enzymes. While they are produced in the liver, elevated levels of these enzymes are often non-specific indicators of problems elsewhere in the body (i.e. you can't be sure of the exact cause of the high value nor can you be certain it is in the liver based on this test alone).

When I first went in to the doctor with my elevated ALT (which I think is the same as SGPT), I was asked if I had recently bruised myself.  Apparently, even mild muscle damage can result in elevated enzyme levels.  Apparently weight lifters (I am not one) often cause damage to their muscles when they do low rep/high weight routines, thereby sometimes effecting their liver enzyme results.

I also got the sense from my doctor that it is not all that unusual for people to have slightly elevated values (look at the normal ranges on the web site I provided).  In my case, to rule out other potential causes, I was tested for Hepatitis, a viral infection which could have been the cause of the elevated enzyme tests.  As I understand it, the reason that I was rejected as a blood donor (and probably you for insurance) was that my liver enzyme test could have been the result of Hepatitis (this was proven to not be the case for me).  I think that you should probably get a Hepatitis test as if you do have Hepatitis, you need to know about it and get treated as it is very serious and is frequently life threatening.  There are three categories of Hepatitis, type A, B, and C.  A person can get type A Hepatitis from ingested food contaminated by fecal matter.  This is an epidemic in third world countries where food handling and sanitary conditions are very poor though I have heard about many cases in the US in my internet research. Type B and C are much more serious (though type A is also very serious) and are often transmitted sexually or by blood transfusion or IV needle sharing.  Hepatitis is much much more contagious than AIDS and infects many more people than AIDS, though one rarely hears about it in the US popular culture.  It is an epidemic is the US, particularly in promiscuous and IV drug using populations.

A second cause of elevated enzyme results comes from liver damage that is the result of drinking.  My understanding is that drinking damages liver cells, though I get the sense that casual alcohol use is not a problem (with regard to the enzyme tests) for most people.

A third cause of elevated enzyme results comes from a condition called fatty liver.  You can learn about this at:
http://www.endowsec.com/pated/ecdlv37.htm
In my case, an abdominal ultrasound revealed this condition.  I still don't know why this was discovered in me, though I have read that you don't have to be grossly overweight to have this condition (this is part of the reason that I decided to start a more healthy lifestyle).  The above web site does a much better job than I could ever do explaining it, but I do understand that heavy drinking can be one of a potential list of causes for this condition.

There are also other causes of high liver enzyme test results which I don't know enough about to comment on, so you are on your  own for these (sorry).

I too had a pain right below my right rib-cage (this is where your liver is located).  I think that at a minimum, you should get screened for Hepatitis (your potential for being infected as revealed by your enzyme tests is probably why your insurance company rejected you).  If you can't afford a doctor, perhaps you could try to find a clinic that could see you and run these tests.

With regard to your diet, I highly recommend a book called Mastering the Zone by Barry Sears Ph.D. This book is the basis for a diet that has swept America (you will be able to find it at ANY bookstore) and has done wonders for me.  It is not a fad, and does not require drastic changes to your diet.  All of the recommendations in the book are strongly supported by clinical data.  You will definitely not be disappointed.  I have not repeated my enzyme tests, but will soon and hope that my weight loss helps to lower them.

I hope that the information that I have written is helpful to you.    I'll check back again later if you need any additional info that I can provide as a lay person.

One last note (and hint):  All blood donation centers run a liver enzyme test prior to donation with a machine that uses a pin ***** blood sample and the machine gives the result in less than a minute.  Perhaps you could find someone to run this test for you.  Be aware however that this test is not as accurate at the one in a blood lab.  Good luck!

----------------------------------------------
For the second poster 6'4", and 165 lbs, see a specialist.  Don't lose sleep about the colonoscopy.  You'll survive, and hopefully will be able to figure out what is going on.  Good luck!
Blank
Avatar_n_tn
Re: James

Before I say anything here, I want to emphasize that I am not a doctor, but am glad to share what I have learned if it can be of help to you.

You might also want to check out: http://www.hepcfoundation.org/disi_bloodtest.html

SGPT (alanine transaminase) and SGOT (aspartate transaminase) are liver enzymes. While they are produced in the liver, elevated levels of these enzymes are often non-specific indicators of problems elsewhere in the body (i.e. you can't be sure of the exact cause of the high value nor can you be certain it is in the liver based on this test alone).

When I first went in to the doctor with my elevated ALT (which I think is the same as SGPT), I was asked if I had recently bruised myself.  Apparently, even mild muscle damage can result in elevated enzyme levels.  Apparently weight lifters (I am not one) often cause damage to their muscles when they do low rep/high weight routines, thereby sometimes effecting their liver enzyme results.

I also got the sense from my doctor that it is not all that unusual for people to have slightly elevated values (look at the normal ranges on the web site I provided).  In my case, to rule out other potential causes, I was tested for Hepatitis, a viral infection which could have been the cause of the elevated enzyme tests.  As I understand it, the reason that I was rejected as a blood donor (and probably you for insurance) was that my liver enzyme test could have been the result of Hepatitis (this was proven to not be the case for me).  I think that you should probably get a Hepatitis test as if you do have Hepatitis, you need to know about it and get treated as it is very serious and is frequently life threatening.  There are three categories of Hepatitis, type A, B, and C.  A person can get type A Hepatitis from ingested food contaminated by fecal matter.  This is an epidemic in third world countries where food handling and sanitary conditions are very poor though I have heard about many cases in the US in my internet research. Type B and C are much more serious (though type A is also very serious) and are often transmitted sexually or by blood transfusion or IV needle sharing.  Hepatitis is much much more contagious than AIDS and infects many more people than AIDS, though one rarely hears about it in the US popular culture.  It is an epidemic is the US, particularly in promiscuous and IV drug using populations.

A second cause of elevated enzyme results comes from liver damage that is the result of drinking.  My understanding is that drinking damages liver cells, though I get the sense that casual alcohol use is not a problem (with regard to the enzyme tests) for most people.

A third cause of elevated enzyme results comes from a condition called fatty liver.  You can learn about this at:
http://www.endowsec.com/pated/ecdlv37.htm
In my case, an abdominal ultrasound revealed this condition.  I still don't know why this was discovered in me, though I have read that you don't have to be grossly overweight to have this condition (this is part of the reason that I decided to start a more healthy lifestyle).  The above web site does a much better job than I could ever do explaining it, but I do understand that heavy drinking can be one of a potential list of causes for this condition.

There are also other causes of high liver enzyme test results which I don't know enough about to comment on, so you are on your  own for these (sorry).

I too had a pain right below my right rib-cage (this is where your liver is located).  I think that at a minimum, you should get screened for Hepatitis (your potential for being infected as revealed by your enzyme tests is probably why your insurance company rejected you).  If you can't afford a doctor, perhaps you could try to find a clinic that could see you and run these tests.

With regard to your diet, I highly recommend a book called Mastering the Zone by Barry Sears Ph.D. This book is the basis for a diet that has swept America (you will be able to find it at ANY bookstore) and has done wonders for me.  It is not a fad, and does not require drastic changes to your diet.  All of the recommendations in the book are strongly supported by clinical data.  You will definitely not be disappointed.  I have not repeated my enzyme tests, but will soon and hope that my weight loss helps to lower them.

I hope that the information that I have written is helpful to you.    I'll check back again later if you need any additional info that I can provide as a lay person.

One last note (and hint):  All blood donation centers run a liver enzyme test prior to donation with a machine that uses a pin ***** blood sample and the machine gives the result in less than a minute.  Perhaps you could find someone to run this test for you.  Be aware however that this test is not as accurate at the one in a blood lab.  Good luck!

----------------------------------------------
For the second poster 6'4", and 165 lbs, see a specialist.  Don't lose sleep about the colonoscopy.  You'll survive, and hopefully will be able to figure out what is going on.  Good luck!
Blank
Avatar_n_tn
Re: James

Before I say anything here, I want to emphasize that I am not a doctor, but am glad to share what I have learned if it can be of help to you.

You might also want to check out: http://www.hepcfoundation.org/disi_bloodtest.html

SGPT (alanine transaminase) and SGOT (aspartate transaminase) are liver enzymes. While they are produced in the liver, elevated levels of these enzymes are often non-specific indicators of problems elsewhere in the body (i.e. you can't be sure of the exact cause of the high value nor can you be certain it is in the liver based on this test alone).

When I first went in to the doctor with my elevated ALT (which I think is the same as SGPT), I was asked if I had recently bruised myself.  Apparently, even mild muscle damage can result in elevated enzyme levels.  Apparently weight lifters (I am not one) often cause damage to their muscles when they do low rep/high weight routines, thereby sometimes effecting their liver enzyme results.

I also got the sense from my doctor that it is not all that unusual for people to have slightly elevated values (look at the normal ranges on the web site I provided).  In my case, to rule out other potential causes, I was tested for Hepatitis, a viral infection which could have been the cause of the elevated enzyme tests.  As I understand it, the reason that I was rejected as a blood donor (and probably you for insurance) was that my liver enzyme test could have been the result of Hepatitis (this was proven to not be the case for me).  I think that you should probably get a Hepatitis test as if you do have Hepatitis, you need to know about it and get treated as it is very serious and is frequently life threatening.  There are three categories of Hepatitis, type A, B, and C.  A person can get type A Hepatitis from ingested food contaminated by fecal matter.  This is an epidemic in third world countries where food handling and sanitary conditions are very poor though I have heard about many cases in the US in my internet research. Type B and C are much more serious (though type A is also very serious) and are often transmitted sexually or by blood transfusion or IV needle sharing.  Hepatitis is much much more contagious than AIDS and infects many more people than AIDS, though one rarely hears about it in the US popular culture.  It is an epidemic is the US, particularly in promiscuous and IV drug using populations.

A second cause of elevated enzyme results comes from liver damage that is the result of drinking.  My understanding is that drinking damages liver cells, though I get the sense that casual alcohol use is not a problem (with regard to the enzyme tests) for most people.

A third cause of elevated enzyme results comes from a condition called fatty liver.  You can learn about this at:
http://www.endowsec.com/pated/ecdlv37.htm
In my case, an abdominal ultrasound revealed this condition.  I still don't know why this was discovered in me, though I have read that you don't have to be grossly overweight to have this condition (this is part of the reason that I decided to start a more healthy lifestyle).  The above web site does a much better job than I could ever do explaining it, but I do understand that heavy drinking can be one of a potential list of causes for this condition.

There are also other causes of high liver enzyme test results which I don't know enough about to comment on, so you are on your  own for these (sorry).

I too had a pain right below my right rib-cage (this is where your liver is located).  I think that at a minimum, you should get screened for Hepatitis (your potential for being infected as revealed by your enzyme tests is probably why your insurance company rejected you).  If you can't afford a doctor, perhaps you could try to find a clinic that could see you and run these tests.

With regard to your diet, I highly recommend a book called Mastering the Zone by Barry Sears Ph.D. This book is the basis for a diet that has swept America (you will be able to find it at ANY bookstore) and has done wonders for me.  It is not a fad, and does not require drastic changes to your diet.  All of the recommendations in the book are strongly supported by clinical data.  You will definitely not be disappointed.  I have not repeated my enzyme tests, but will soon and hope that my weight loss helps to lower them.

I hope that the information that I have written is helpful to you.    I'll check back again later if you need any additional info that I can provide as a lay person.

One last note (and hint):  All blood donation centers run a liver enzyme test prior to donation with a machine that uses a pin ***** blood sample and the machine gives the result in less than a minute.  Perhaps you could find someone to run this test for you.  Be aware however that this test is not as accurate at the one in a blood lab.  Good luck!

----------------------------------------------
For the second poster 6'4", and 165 lbs, see a specialist.  Don't lose sleep about the colonoscopy.  You'll survive, and hopefully will be able to figure out what is going on.  Good luck!
Blank
Avatar_n_tn
Re: James

Before I say anything here, I want to emphasize that I am not a doctor, but am glad to share what I have learned if it can be of help to you.

You might also want to check out: http://www.hepcfoundation.org/disi_bloodtest.html

SGPT (alanine transaminase) and SGOT (aspartate transaminase) are liver enzymes. While they are produced in the liver, elevated levels of these enzymes are often non-specific indicators of problems elsewhere in the body (i.e. you can't be sure of the exact cause of the high value nor can you be certain it is in the liver based on this test alone).

When I first went in to the doctor with my elevated ALT (which I think is the same as SGPT), I was asked if I had recently bruised myself.  Apparently, even mild muscle damage can result in elevated enzyme levels.  Apparently weight lifters (I am not one) often cause damage to their muscles when they do low rep/high weight routines, thereby sometimes effecting their liver enzyme results.

I also got the sense from my doctor that it is not all that unusual for people to have slightly elevated values (look at the normal ranges on the web site I provided).  In my case, to rule out other potential causes, I was tested for Hepatitis, a viral infection which could have been the cause of the elevated enzyme tests.  As I understand it, the reason that I was rejected as a blood donor (and probably you for insurance) was that my liver enzyme test could have been the result of Hepatitis (this was proven to not be the case for me).  I think that you should probably get a Hepatitis test as if you do have Hepatitis, you need to know about it and get treated as it is very serious and is frequently life threatening.  There are three categories of Hepatitis, type A, B, and C.  A person can get type A Hepatitis from ingested food contaminated by fecal matter.  This is an epidemic in third world countries where food handling and sanitary conditions are very poor though I have heard about many cases in the US in my internet research. Type B and C are much more serious (though type A is also very serious) and are often transmitted sexually or by blood transfusion or IV needle sharing.  Hepatitis is much much more contagious than AIDS and infects many more people than AIDS, though one rarely hears about it in the US popular culture.  It is an epidemic is the US, particularly in promiscuous and IV drug using populations.

A second cause of elevated enzyme results comes from liver damage that is the result of drinking.  My understanding is that drinking damages liver cells, though I get the sense that casual alcohol use is not a problem (with regard to the enzyme tests) for most people.

A third cause of elevated enzyme results comes from a condition called fatty liver.  You can learn about this at:
http://www.endowsec.com/pated/ecdlv37.htm
In my case, an abdominal ultrasound revealed this condition.  I still don't know why this was discovered in me, though I have read that you don't have to be grossly overweight to have this condition (this is part of the reason that I decided to start a more healthy lifestyle).  The above web site does a much better job than I could ever do explaining it, but I do understand that heavy drinking can be one of a potential list of causes for this condition.

There are also other causes of high liver enzyme test results which I don't know enough about to comment on, so you are on your  own for these (sorry).

I too had a pain right below my right rib-cage (this is where your liver is located).  I think that at a minimum, you should get screened for Hepatitis (your potential for being infected as revealed by your enzyme tests is probably why your insurance company rejected you).  If you can't afford a doctor, perhaps you could try to find a clinic that could see you and run these tests.

With regard to your diet, I highly recommend a book called Mastering the Zone by Barry Sears Ph.D. This book is the basis for a diet that has swept America (you will be able to find it at ANY bookstore) and has done wonders for me.  It is not a fad, and does not require drastic changes to your diet.  All of the recommendations in the book are strongly supported by clinical data.  You will definitely not be disappointed.  I have not repeated my enzyme tests, but will soon and hope that my weight loss helps to lower them.

I hope that the information that I have written is helpful to you.    I'll check back again later if you need any additional info that I can provide as a lay person.

One last note (and hint):  All blood donation centers run a liver enzyme test prior to donation with a machine that uses a pin ***** blood sample and the machine gives the result in less than a minute.  Perhaps you could find someone to run this test for you.  Be aware however that this test is not as accurate at the one in a blood lab.  Good luck!

----------------------------------------------
For the second poster 6'4", and 165 lbs, see a specialist.  Don't lose sleep about the colonoscopy.  You'll survive, and hopefully will be able to figure out what is going on.  Good luck!
Blank
Avatar_n_tn
Re: James

Before I say anything here, I want to emphasize that I am not a doctor, but am glad to share what I have learned if it can be of help to you.

You might also want to check out: http://www.hepcfoundation.org/disi_bloodtest.html

SGPT (alanine transaminase) and SGOT (aspartate transaminase) are liver enzymes. While they are produced in the liver, elevated levels of these enzymes are often non-specific indicators of problems elsewhere in the body (i.e. you can't be sure of the exact cause of the high value nor can you be certain it is in the liver based on this test alone).

When I first went in to the doctor with my elevated ALT (which I think is the same as SGPT), I was asked if I had recently bruised myself.  Apparently, even mild muscle damage can result in elevated enzyme levels.  Apparently weight lifters (I am not one) often cause damage to their muscles when they do low rep/high weight routines, thereby sometimes effecting their liver enzyme results.

I also got the sense from my doctor that it is not all that unusual for people to have slightly elevated values (look at the normal ranges on the web site I provided).  In my case, to rule out other potential causes, I was tested for Hepatitis, a viral infection which could have been the cause of the elevated enzyme tests.  As I understand it, the reason that I was rejected as a blood donor (and probably you for insurance) was that my liver enzyme test could have been the result of Hepatitis (this was proven to not be the case for me).  I think that you should probably get a Hepatitis test as if you do have Hepatitis, you need to know about it and get treated as it is very serious and is frequently life threatening.  There are three categories of Hepatitis, type A, B, and C.  A person can get type A Hepatitis from ingested food contaminated by fecal matter.  This is an epidemic in third world countries where food handling and sanitary conditions are very poor though I have heard about many cases in the US in my internet research. Type B and C are much more serious (though type A is also very serious) and are often transmitted sexually or by blood transfusion or IV needle sharing.  Hepatitis is much much more contagious than AIDS and infects many more people than AIDS, though one rarely hears about it in the US popular culture.  It is an epidemic is the US, particularly in promiscuous and IV drug using populations.

A second cause of elevated enzyme results comes from liver damage that is the result of drinking.  My understanding is that drinking damages liver cells, though I get the sense that casual alcohol use is not a problem (with regard to the enzyme tests) for most people.

A third cause of elevated enzyme results comes from a condition called fatty liver.  You can learn about this at:
http://www.endowsec.com/pated/ecdlv37.htm
In my case, an abdominal ultrasound revealed this condition.  I still don't know why this was discovered in me, though I have read that you don't have to be grossly overweight to have this condition (this is part of the reason that I decided to start a more healthy lifestyle).  The above web site does a much better job than I could ever do explaining it, but I do understand that heavy drinking can be one of a potential list of causes for this condition.

There are also other causes of high liver enzyme test results which I don't know enough about to comment on, so you are on your  own for these (sorry).

I too had a pain right below my right rib-cage (this is where your liver is located).  I think that at a minimum, you should get screened for Hepatitis (your potential for being infected as revealed by your enzyme tests is probably why your insurance company rejected you).  If you can't afford a doctor, perhaps you could try to find a clinic that could see you and run these tests.

With regard to your diet, I highly recommend a book called Mastering the Zone by Barry Sears Ph.D. This book is the basis for a diet that has swept America (you will be able to find it at ANY bookstore) and has done wonders for me.  It is not a fad, and does not require drastic changes to your diet.  All of the recommendations in the book are strongly supported by clinical data.  You will definitely not be disappointed.  I have not repeated my enzyme tests, but will soon and hope that my weight loss helps to lower them.

I hope that the information that I have written is helpful to you.    I'll check back again later if you need any additional info that I can provide as a lay person.

One last note (and hint):  All blood donation centers run a liver enzyme test prior to donation with a machine that uses a pin ***** blood sample and the machine gives the result in less than a minute.  Perhaps you could find someone to run this test for you.  Be aware however that this test is not as accurate at the one in a blood lab.  Good luck!

----------------------------------------------
For the second poster 6'4", and 165 lbs, see a specialist.  Don't lose sleep about the colonoscopy.  You'll survive, and hopefully will be able to figure out what is going on.  Good luck!
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Re: James

Before I say anything here, I want to emphasize that I am not a doctor, but am glad to share what I have learned if it can be of help to you.

You might also want to check out: http://www.hepcfoundation.org/disi_bloodtest.html

SGPT (alanine transaminase) and SGOT (aspartate transaminase) are liver enzymes. While they are produced in the liver, elevated levels of these enzymes are often non-specific indicators of problems elsewhere in the body (i.e. you can't be sure of the exact cause of the high value nor can you be certain it is in the liver based on this test alone).

When I first went in to the doctor with my elevated ALT (which I think is the same as SGPT), I was asked if I had recently bruised myself.  Apparently, even mild muscle damage can result in elevated enzyme levels.  Apparently weight lifters (I am not one) often cause damage to their muscles when they do low rep/high weight routines, thereby sometimes effecting their liver enzyme results.

I also got the sense from my doctor that it is not all that unusual for people to have slightly elevated values (look at the normal ranges on the web site I provided).  In my case, to rule out other potential causes, I was tested for Hepatitis, a viral infection which could have been the cause of the elevated enzyme tests.  As I understand it, the reason that I was rejected as a blood donor (and probably you for insurance) was that my liver enzyme test could have been the result of Hepatitis (this was proven to not be the case for me).  I think that you should probably get a Hepatitis test as if you do have Hepatitis, you need to know about it and get treated as it is very serious and is frequently life threatening.  There are three categories of Hepatitis, type A, B, and C.  A person can get type A Hepatitis from ingested food contaminated by fecal matter.  This is an epidemic in third world countries where food handling and sanitary conditions are very poor though I have heard about many cases in the US in my internet research. Type B and C are much more serious (though type A is also very serious) and are often transmitted sexually or by blood transfusion or IV needle sharing.  Hepatitis is much much more contagious than AIDS and infects many more people than AIDS, though one rarely hears about it in the US popular culture.  It is an epidemic is the US, particularly in promiscuous and IV drug using populations.

A second cause of elevated enzyme results comes from liver damage that is the result of drinking.  My understanding is that drinking damages liver cells, though I get the sense that casual alcohol use is not a problem (with regard to the enzyme tests) for most people.

A third cause of elevated enzyme results comes from a condition called fatty liver.  You can learn about this at:
http://www.endowsec.com/pated/ecdlv37.htm
In my case, an abdominal ultrasound revealed this condition.  I still don't know why this was discovered in me, though I have read that you don't have to be grossly overweight to have this condition (this is part of the reason that I decided to start a more healthy lifestyle).  The above web site does a much better job than I could ever do explaining it, but I do understand that heavy drinking can be one of a potential list of causes for this condition.

There are also other causes of high liver enzyme test results which I don't know enough about to comment on, so you are on your  own for these (sorry).

I too had a pain right below my right rib-cage (this is where your liver is located).  I think that at a minimum, you should get screened for Hepatitis (your potential for being infected as revealed by your enzyme tests is probably why your insurance company rejected you).  If you can't afford a doctor, perhaps you could try to find a clinic that could see you and run these tests.

With regard to your diet, I highly recommend a book called Mastering the Zone by Barry Sears Ph.D. This book is the basis for a diet that has swept America (you will be able to find it at ANY bookstore) and has done wonders for me.  It is not a fad, and does not require drastic changes to your diet.  All of the recommendations in the book are strongly supported by clinical data.  You will definitely not be disappointed.  I have not repeated my enzyme tests, but will soon and hope that my weight loss helps to lower them.

I hope that the information that I have written is helpful to you.    I'll check back again later if you need any additional info that I can provide as a lay person.

One last note (and hint):  All blood donation centers run a liver enzyme test prior to donation with a machine that uses a pin ***** blood sample and the machine gives the result in less than a minute.  Perhaps you could find someone to run this test for you.  Be aware however that this test is not as accurate at the one in a blood lab.  Good luck!

----------------------------------------------
For the second poster 6'4", and 165 lbs, see a specialist.  Don't lose sleep about the colonoscopy.  You'll survive, and hopefully will be able to figure out what is going on.  Good luck!
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Joe,

Thank you so much for your response.  I do appreciate everything you offered in the way of information and will follow up on all of it.  Thank you again!!  Best of luck with you upcoming test!
-  James
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MY SGPT was high 58, doctor said to lower my alcohol intake and quit taking tylenol then retest in 2-3 weeks.  Well I don't drink and I don't take tylenol, so now what?
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Retest is a few weeks anyway.  It is not that uncommon to have slightly evevated values.
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For anyone who is interested.  My follow up liver enzyme tests were way down well into the normal range.  Three cheers for the book "Mastering the Zone".  The right diet did the trick for me.  The fatty liver is gone.  I was only mildly overweight and the change in diet did the trick for me.
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I posted this above for Mike, but it applies to your situation as well:  I read your question and the Doctor's response. My layman's opinion is you should be screened for hemachromatosis (iron overload disease.) You are the right age for symptoms to begin to show. At 39, I first showed elevated ALT.

Simple blood tests can determine if you should be evaluated further for HH. Ask you doctor to check your ferritin levels and transferrin saturation (serum iron divided by Total Iron Binding Capacity (TIBC). A saturation above 50% and a ferritin above 300 are suspect. Next step is probably a genetic test (Michigan State University will send you a cheek brush kit fairly cheap and give you a result in ten days.)

Treatment is de-ironing through weekly phlebotomies and will save damage to liver, heart and other organs. Iron levels can be maintained by several phlebotomies per year.

This may not be your problem, but it would be a tragedy not to rule it out. Early treatment is the key to a normal life. Check out American Hemachromatosis Society: www.emi.net ( I also had right quadrant aching and IBS symptoms which disappeared six months after de-ironing.  Good luck.

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Correction:  American Hemachromatosis Society website is:

http://www.americanhs.org
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CAN YOU PLEASE TELL ME THE AVERAGE RANGE LEVEL IN GSOT TESTING.
WHAT IS CONSIDER A NORMAL LEVEL READING, MODERATE, SEVERE ECT.

THANK YOU!
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SGOT - reference range is 10-45 U/L according to ICL Labs.
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I'm 34, 140 lb, 5'6".  My insurance company just informed me that my SGPT is 91.  The normal levels should be between 0 and 45.  They tested me in december 1999. In november 1998 I felt
heartburn and pain in the lowest right rib, the ultrasouind showed nothing.  Should I worry about this?  Is there a conection between SGPT and heartburn?
thanks

mauricio mora
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I have Anklosing Spondylitis. I'm taking Hydrocodone,and indomethacin. For spine pain and inflamation (inflammation). For two years. It seems my stomach is always bloated. I'm a vegetarian. Although I love my sweets. I was tested for hepatitis- it was neg. Blood tests were taken for my liver. All levels were fine, except mt Transaminase level AST/SGOT was 128. Normal was 15-46. The doctors are not sure why the level is a little high. But not to worry. I've been taking artichoke Extract along with my medication, to hopefully prevent the medication from doing any damage to my liver. But my stomach continues to be bloated. Although in the morning it seems to have gone down. I'm a 43 yaer old. I know I need to change some of my eating habits. But do you have any suggestions. Next Im going to try Livatone. And have previously tried Milk Thisle. Thank You.
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