I am a 30 yr old female with a history of autonomic neuropathy (unknown autoimmune cause), gastroparesis, and phopholipid antibody syndrome. For as long as I can remember, I've had digestive problems that appear to set off other symptoms including joint pain in foot, ankle, and hand, mouth sores, abdominal pain and cramping, and low grade fevers. My gastroenterologist tested me for antibody ASCA IgA & ASCA IgG. Both came back moderate to high positive. I was told it looks like Crohn's Disease. I had a upper and lower endoscopy done which showed "moderate hyperemia and erythema of distal esophagus, diffuse gastritis, and mild chronic inflammation of duodenum" according to biopsy results. H-pylori testing was negative. The small bowel follow-through appeared to be normal. My gastroenterologist still says most likely Crohn's but not 100% sure. She seems to think that the gastroparesis is a result of inflammation, and that Crohn's is probably the autoimmune disease responsible for my autonomic neuropathy. My father passed away at 52 years old. He had been ill most of his life with many digestive problems (pancreatitis, small bowel dysmotility), no single cause identified though. He also had phospholipid antibodies and joint pain. Also, my paternal grandmother has had bowel problems as well as joint pain her whole life. My questions...based on my biopsies, does this sound like Crohn's? Is it possible to have moderate to high levels of ASCA antibodies without having Crohn's Disease? Is Crohn's/inflammatory bowel disease genetic?