Metformin to decrease miscarriage chance, how much?

[ntaylor]

Hi all! I'm worried because I'll hopefully ovulate soon from clomid and I'm only up to 750mg per day met. I'm taking it so I hopefully will not miscarry. I really think it's the reason for my 3 miscarriages. Do you think that's enough to help until I can bump it up? My fasting blood sugar was only 96, slightly higher and my male hormone levels are all normal. I weigh 136 pounds and am eating healthier to try and make a healthy pregnancy. Does that sound ok? I am planning on bumping up to 1000 in a week, I just get so sick. Thank you, I'm just a worry wart..

[mlb1234]

I was on the XR until I got to 12 weeks - then I stopped it with no problems.  I would start taking the prometrium a couple days after ovulation so the uterus is ready for implantation should conception occur.  And don't go off of it until after you are positive it is a negative HPT (like at 17 days past ovulation).  If the HPT is positive - stay on the prometrium!!  But I would also OK it with your doctor first.  That's great that you are on the aspirin and folic acid already.  Don't be jealous - it will happen for you too!!  I thought my time would never come but once I tried the femara it happened on the first cycle!  I have heard this from other women as well.  On femara I ovulated on day 13 but with the help of a trigger shot of HCG.  At day 13 the one follicle I had was 22mm.  I never tried clomid.  I think  you have all the bases covered now - best of luck for a successful cycle!!!!  I am excited to hear good news from you!!!

[ntaylor]

I actually am on aspirin and 4g folic acid as I am heterozygous for mthfr, I've been taking both for a few months trying to prepare. So that's good I guess! Your right, maybe if I could ovulate sooner that really might help me. I'm on on the XR, are you taking it? Do you think I should take prometrium after I ovulate or wait for a positive preg test? I'm trying to decide about that next. Congratulations! I have to say I'm jealous. I hope I get to 21 weeks some day. That's great. When did you ovulate on the femara?

[mlb1234]

I wouldn't worry about the specifics too much - at least you are on it and your blood sugar was not that high to begin with.  Plus you stop it at 12 weeks anyways.  Your m/c's could have been from ovulating so late which the clomid will help with.  And I remember you said you would start prometrium.  This will also help.  If you have any more unexplained miscarriages you can inquirre about extra folic acid and baby aspirin as well.  I took both until 12 weeks too.  Overall though I really feel the femara helped me - the egg was better quality and I ovulated sooner.  I am going on 21 weeks now and that's all I know.  You are doing you best to prevent any more miscarriages.  Now you just need the BFP!!  Good luck!  (Also are you on the metformin-XR (extrended release)???  This can help with the stomach problems...I had none.  I have heard there are more problems with the non-XR formula.)

[mlb1234]

I wouldn't worry about the specifics too much - at least you are on it and your blood sugar was not that high to begin with.  Plus you stop it at 12 weeks anyways.  Your m/c's could have been from ovulating so late which the clomid will help with.  And I remember you said you would start prometrium.  This will also help.  If you have any more unexplained miscarriages you can inquirre about extra folic acid and baby aspirin as well.  I took both until 12 weeks too.  Overall though I really feel the femara helped me - the egg was better quality and I ovulated sooner.  I am going on 21 weeks now and that's all I know.  You are doing you best to prevent any more miscarriages.  Now you just need the BFP!!  Good luck!  (Also are you on the metformin-XR (extrended release)???  This can help with the stomach problems...I had none.  I have heard there are more problems with the non-XR formula.)