Beta Negative. I'm devastated...

[bella537]

After 3 ivf tries my last try, beta was negative on monday 10th.  I'm trying really hard to keep it together not just for myself but for my wonerful husband. He is such a Godsend. My mother keeps pushing adoption and we haven't ruled that out but we're not giving up on ivf yet. She's driving me crazy. I'm here waiting for AF to start since i stopped my meds such a wonderful thing to look forward to after being told, yet again, you're not pregnant, huh?

[YvetteY]

I'm sorry that you're IVF cycle didn't work.   I know I can't even begin to say anything that will make you feel better, but I wish I could.  I can definitely empathize with you.   Again I'm sooo sorry didn't work.  

[carina1]

I am so sorry to hear about your BFN.  I went through a failed first IVF this past August and felt completely devastated.  Please know that you are not alone on this journey--  it never ceases to amaze me how many wonderful women go through this, while other women who do not seem ready to have children, have no trouble at all.  There must be some master plan somewhere and I suppose that we just need to have faith.  I'll be thinking of you and praying for you to have strength and patience.  Please let us know how you continue to do.

[keis]

Natural Killer Cell Activity (cytotoxicity)
NK cells are lymphocytes that carry a CD56 marker. They are present in progestational endometrium during the secretory phase of the menstrual cycle and in the decidua during pregnancy. Decidual NK cells have a dichotomous immunological function. During early pregnancy, NK cells release TH2 related cytokines that promote implantation and play a pivotal role in regulating normal trophoblastic migration and orderly placentation (21). It has been suggested that women who have a deficiency of CD56+, NK cells are prone to aggressive invasion of the trophoblast, leading to pregnancy complications, such as placenta percreta/increta (22).
Women with recurrent pregnancy losses, organic pelvic disease (endometriosis) and primary autoimmune conditions (such as rheumatoid arthritis and lupus erythematosis), have been found to demonstrate elevated levels of NK cells that in addition to having CD56+ expression, also carry a CD16+ marker (23). Such CD56+/16+ NK cells are believed to be highly susceptible to activation by certain TH-1cytokines, especially Interleukin-2. Activated Natural Killer (NKa) cells release a number of TH-1 cytokines, such as, interferon-gamma, and tumor necrosis factor-alpha (TNF-alpha), which cause excessive apoptosis of invading trophoblast cells, resulting in failed or compromised implantation (24). This endogenous TNF-alpha production seems also to be involved in the induction of NK cell activity and the further proliferation of CD56+, CD16+ NK cells (25). Neutralizing antibodies to TNF inhibit the IL-2 induced cytotoxicity and LAK cell proliferation. It is reported that monoclonal antibodies to both p55 and p75 TNFR inhibit IL-2 induced NK activity (26).


Immunoglobulin (IVIG) has an ability to down-regulate and deactivate peripheral blood NKa cells ( and probably also actvated T-cells too) within one to two weeks of administration (27). In fact, the in-vitro test used to measure NKa involves the administration of titrated dosages of IVIG to target celles ( so called K562 cells) to diagnose Nka+ and to try and determine the amount of IVIG necessary to neutralize activation.
These findings strongly support the idea that it is the detection of NKa rather than APA+ that represents the a prognostic marker by which women with an increased risk for failed implantation can be identified and that the administration of IVIG to women with increased NKa might, by down-regulating NKa, improve implantation rates and IVF outcome.





    
  



  
    
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[shellcj]

Bella, I'm so sorry for your BFN.  I'm on my 3rd ivf, my 1st didn't take at all, 2nd was a chemical and now I hope and pray everyday, every night, mid day, midnight...you know what I mean.

Good luck and please try and stay positive.

[bella537]

What's an NKC test?  My first RE the one that referred me to fertility clinic mentioned that a damaged tube could dump bad fluid into my uterus couple years ago. When my DH and I consulted with him on our first visit, I brought this us and asked should  I have it removed and he blew off the question mostly like it wasn't an important thing so tomorrow when my fertility Doc (RE) calls I'm going to ask him about this. Thanks for support and info. God bless.

[keis]

We will soon get out BFP'S just keep the faith and keep trying if you can, God will deliver for us soon. I know it's hard to keep the faith and keep praying, but you must. Good luck to everyone including myself.

[keis]

Bella have you thought about having you tubes removed, because if you have damage tubes they can have this damage fluid in them and can leak down and kill your embryos? It doesn’t matter how good your embryos are, Each IVF i had so far embryos are always great, but they don't implant, so look into that. That is why I had my tubes removed, they were damage anyways and I was pregnant last year and it ended in a tubal. I removed my tubes to up my chance at IVF and I pray to god that it works I'll let you know the outcome when I get there. I had blocked tubes and had to failed ivfs and now I have no tubes and I’m only 26yrs old not that age matters, but I never thought this could happen to me, but it did and also have you had the NKC test done? I just had it done like two weeks ago and everything is ok with me, so I’ll be starting in November if all stays well.


Good luck to you.

[Baby Vol]

Oh Im so sorry for you and your DH. I got beta back today as well and mine was also BFN. I am 5 days late too. It sucks so bad, every month, the same thing, over and over. I hate it. I am never late so i just KNEW this was it. I am so bummed, I am bummed for you too. Please hang in there and know we are with you! :-)

[pcarsey]

I am so sorry!! You are definitely a woman of strength and courage!! A true Inspiration for not giving up!! I hope things turn out for you and your DH! I will be saying a special prayer for you!! XOXO ~Patty

[SDScientist]

I have gone through two cycles.  The first one BFN and I am awaiting the second BFN Friday.  I understand how you feel and my heart goes out to you.  

[twinkster]

I'm so sorry to hear your news.  I have a friend who just got a BFN on her first IVF....she is devastated as well. She won't be trying again simply because of the cost.  I hope whatever you choose to do, you will soon have a child of your own.

I also agree with Nikki10.  Adoption can be wonderful, but for those of us who have had a failed adoption, it is just like losing your child to death and can be very hard to overcome.  7 months ago I had a little girl that I THOUGHT would be mine forever. I had her  from 4 months of age to 5 1/2 months (had her for 6 weeks), and the mother changed her mind.  Losing her was the worst experience of my life, and now TTC is the 2nd worst.  What some of us have to go through to have what others seem to get so effortlessly.  It just seems so unfair sometimes.

Keep your head up.  There are still options (yes, including adoption, but it isn't your only option).  I know how you feel.  Every single BFN feels like a piece of your heart is being ripped out.  Just remember, your day will come.  Keep believing that and you will get through this latest heartache.

Take care

[bella537]

Endometriosis, left tube severly damaged fully blocked and PCOS.  I'm sorry your last 2 didn't turn out either. It's hard. I produced some good eggs on ivf and even on the frozen cycles they looked pretty good some 4's out of 5 top rating, but no pregnancy. My first ivf I became pregant but miscarried twins after about 8 1/2 9 weeks.

[keis]

Hello Bella,


I'm really sorry about your BFN I have done 2 rounds of Ivf and both times(BFN) My husband and I going try for  3rd one maybe in Nov if all goes well. I had my tubes removed back in June of this year, so maybe that will improve our chance. I'll pray for you.
If you don't mind me asking what is your cause of infertility

[bella537]

thanks, yeah my first husband refused to even consider adoption just for that very reason. I feel for you and am so sorry such a horrible thing happened.  I have  to wait a month in between trying anything with the RE I go to. He won't do IVF back to back and it's so darn expensive so we have to invent some money somehow, haha.  But thank you for the advice and well wishes to you too.  Jeremiah 29:11 helps me refocus sometimes but we still have our down moments. Overall, I have been trying since 1992, with about 1 1/2 years off not trying. I can't believe I'm still doing this...

[nikki10]

I completely understand we got the BFN on Monday to, this was my first time around and waiting for AF to try again.  As for adoption it can be great but also devastating, we had a little girl from 3days old to 9 months and the adoption was revoked because her family changed their minds, it to can be a hard and emotional process.  I am not saying this to get you down just to keep you aware of the risks.  Keep your head up and follow your dreams hopefully next cycle we will both have BFP!!!!!!!

[bella537]

thanks so much you guys! I needed a boost. It's so hard, financially too as we all know. I haven't looked into donors yet. My ovaries produced good eggs on the ivf even though I have PCOS but I am getting ready to turn 37. I'll look into the book.  Thanks again to you both!

[paranoidpattie]

Sorry about your beta.  I could not imagine how upset you must feel and I can only pray for you to have strength and patience.  I hope you will have much success with your next attempt.  That's right, your NEXT attempt, don't give up!!

Best of luck!

Hugz!!

[dsmommy]

So sorry to hear the news.  Don't give up though.  As i'm sure you have read on here there are many success stories after several attempts and way too much medication (j/k).  It's never too late....there is a plan....we just don't always understand it!  Also, i have seen many recommended books on here-in fact 40smama recommended "The Secret" and i heard someone else say that is a good book.  Have you looked into donors?  I can understand your desire to have a child yourself before considering adoption but maybe that is the plan.  Stay positive and be thankful for a wonderful supportive husband!  ;)

Dottie