m protein and relation to hiv

[elbar56]

hi
i had an experience with a csw about 11 weeks ago. i had a duo pcr and elisa at 6 weeks neg and another  elisa at 9 weeks neg. the only symptoms ive had is nerve burning  when putting pressure on elbows and parasthesias all over legs and arms. also big toe numbness which is starting to subside after 8 weeks i am not diabetic  my doctor told me i had some m protein both kappa and gamma with light chains in a monoclony which was followed by a imunagloabn test which turned out neg
my question is as follows
1 i know that people with hiv sometimes have peripheral neuropathies could i still be positive
2does this protein in my blood have anything to do with hiv as a follow up test turned out to be neg for myleomas
3 is the pcr and elisa duo 100 percent at 6 weeks
4 and if i take another test at 11 weeks would that also be 100 percent conclusive thanks in advance

[Edward W Hook, MD]

No, the neurologic symptoms you describe do not bring any STD to mind.  You'll have to look elsewhere for an explantion.  EWH

[elbar56]

i want to thank you for also relieving my anxiety about  hiv  just one more question  is there any std that would cause neuro symptoms as  i got a sore throat which was the worst i ever had, 10 days after my affair  a warm glass of water would feel like ice going down and the next day i awoke with a buzzing big toe  and then the spreading into my hands and elbows
thanks again and have a happy new year you guys are great

[Edward W Hook, MD]

Welcome to our Forum.  You have asked some specific questions so I will go directly to them:

1.  Peripheral neuropathies in persons with HIV occur in people who have had the infection for years and are in the advanced stages of HIV, not in persons who have recently acquired it.  Your neuropathic pain is not due to HIV (and you don't have HIV)

2.  No.  Monoclonal immunoglobulin’s are not a sign of HIV. In your case, my guess is that the protein abnormalities noted on your immunoelectrophoresis are incidental findings, not an indicator that you have HIV.. They are certainly not due to HIV.

3.  At 6 weeks the ELISA test for HIV would detect over 95% of infections and with a PCR test performed at the same time, you can be confident that you do not have HIV.

4.  You can already be confident that you did not get HIV from your exposure 11 weeks ago.  If you repeat the test now or in the future, they will be negative too.

Hope this helps.  You do not need to worry.  EWH