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Amantadine for TBI
by sarahin, Jun 19, 2008 05:07PM
Has anybody out there experienced a dramatic effect after being prescribed Amantadine for TBI? After a clipping of PCOM aneursym I became increasing fatigued and apathetic- to the point of being close to non-functional. Testing showed I now have a verbal learning deficit, but my MRI is normal. A neurologist decided to treat it as TBI and prescribed the Amantadine. He said it might improve my memory, but what actually happened was a huge change in perception and the disappearance of the fatigue. I felt a "wave" go through my head the first dose follwed by a odd perceptual change. By the second dose I suddenly felt everything around me was "real" again. My neurologist was surprised when I described my reaction to the medication. I know Amantadine can affect dopamine levels, but little else about it's use in TBI. Was my reaction that unusual? Do low dopamine levels normal cause the symptoms I had?
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Amamtadine has been evaluated in clinical trials for its effect on improving mentation and motor function in patients with traumatic brain injury but there is no confirmatory evidence so far. However it has emerged as a reasonable option for improving neuropsycological function in patients with TBI. So I would say your reaction was not unusual at all.