Celeste77 I found something and dont understand?

[whatayear]

Hi celeste agian thank you so much for your time you have no idea how much having you on this forum means to us I hope you are feeling better and your pacs and pvs have settled down....I foudn this while doing research about magnesium and I dont understand any of this...thought maybe you might now or atleast direct me where to find out...thank you :)


Several previous studies suggested that agonistic antibodies directed against g-protein coupled receptors may contribute to human cardiovascular disease. A new study suggests that agonistic beta-adrenoreceptor antibodies may contribute to sinus tachycardia. In that study, more than 50% of patients with inappropriate sinus tachycardia tested positive for the antibody. The antibody was not detected in any of the control subjects. Further studies are needed to demonstrate the functional relevance of agonistic beta-adrenoreceptor antibodies in vivo. Another study determined the effect of magnesium sulfate treatment in

[whatayear]

Hey I think the ones that had the antibodies have POTS.....or they would be a whole different side of IST or something new all together I dont have any autoimine issues but some do and I think that is usually more POTS?????

[sugarpea013]

wow, well maybe there is hope for those of us with IST? I don't know, I'm not so sure I wanted to hear that it may be an auto immune disorder.

Thank you so much deedle, your explanation was wonderful!

[deedle1976]

Testing for anti-andrenorecptor antibodies would have required a long and complicated procedure in the experimental laboratory where the research was conducted. It's not something that is tested for routinely there wouldn't be technique established for doing it in a diagnostic lab.
The link is not proven though. I had a quick look at the abstract from the journal article; It was only one small study with 25 IST patients and 15 healthy controls.
There are probably multiple things that can cause IST. I don't know much about it though I'm afraid. It would be interesting to read the whole paper but it's not available without subscription.

[whatayear]

ahhhh thank you for explaining this to me....how would they test to see if these antibodies were present? Also if they are not there does that mean that you do not have an autoimmune issues with IST.  This could help help really now if they have POTS or IST!

[deedle1976]

Hi there, I hope I'm not being rude as I know this question was not directed at me but I am a molecular biologist so I can explain this for you.

Your heart cells have receptors on them called beta-adrenoreceptors, which are activated when adrenalin binds to them. The adrenaline attaches to the receptors   in a very specific way,  just like a  key  fits into a lock. This activation causes you heart rate to increase.

Now, our immune system produces antibodies that recognise, and bind to, foreign substances (such as bacteria) in a very specific way.
Sometimes though our immune system can produce antibodies that recognise our OWN cells.  This is what happens in Autoimmune conditions.
This study showed that half of all people with IST had these 'auto-antibodies' that bind to their own beta-adrenoreceptors and activate them in the same way as adrenalin does.

So basically the study is suggesting that is caused by an autimmune process.

Sorry if that is not very clear. I'm in a bit of a hurry.