Boceprevir Lab Results

[Rockerforlife]

Good news today...just got back my 2 wk and 4 wk PCR results from the SOC drugs,i got some pretty big log drops...here they are

Base VL...20,600,000
Wk 2  ............54,500...3 log drop from day one
Wk 4.................6150...4 log drop from day one

i almost got a RVR....I get my 2 Wk results from the BOC Dec 30
FULL STEAM AHEAD CAPTAIN

[Fl_Gator]

4 log drop in 4 weeks....That's really great isn't it?...RVR would have been UND by week 4?

[Rockerforlife]

Not too shabby...better than a kick in the A.SS...with numbers like this from just the SOC drugs....i wnot really be able to tell now if the BOC drugs are real or not....cause looks like ill be UN by my next blood test in 2 wks regardless in i did the BOC or not....thats a bummer...BTW...my nusre again says i will recieve all full results from the BOC drugs too...they have to tell us....but the only peolpe who really know if we get the real stuff are the big guns at the Schring and Plough

[Marcia2202]

Just woke up to these wonderful news!!!! Congratulations bro', I'm so happy for you. Wait until you show them viruses how the blue man really rocks!!!!!

I am so so rooting for you!!! You're gonna make it big time my dear brother!!!

Hugs, Marcia

[Fl_Gator]

what GT are you? you are only taking SOC and had a 4 log drop in 4 weeks? didn't you treat once already? if so what was your 4 week response at that time?

I wish I could have access to my VL info...well...I believe they will release the info after 72 weeks....I think...I'll have to read my paperwork again...I have no memory cells left in my brain.

[epiphiny]

Way to go Rocker!!!  Congrats!!

[Marcia2202]

He is geno 1 and is doing the BOCEP trial for relapsers/non responders, lead in 4 weeks with SOC then they either get the BOC for 24 weeks or continue SOC and introduce bocep at a later stage (I think at 24 weeks) depending in which arm of the study.

[Rockerforlife]

My VL drop with my first TX back in 2006 are as follows

Base VL=23,600,000
WK 4...........318,000
WK 8...............2850
WK 12...............475


NO 2 wk was done in that trial... in this current trial i  seem too be gettn better rssults...as Marcia describes my protcol..shes bang on

[Rockerforlife]

my 2 weel WAS NOT done...i meant to say...its 5.30 am here...just waking up

[Rockerforlife]

i will be assigned to one of these 3 arms




Arm 1: Placebo Comparator
PegIntron (PEG) + Ribavirin (RBV) (weight-based dosing [WBD]) for 4 weeks followed by boceprevir placebo + PEG + RBV (WBD) for 44 weeks with 24 weeks post-treatment follow-up



Arm 2: Experimental
Subjects in Arm 2 will be assigned either a 36-week or 48-week course of therapy based on their HCV-RNA status at Treatment Week 8.

PEG + RBV (WBD) for 4 weeks followed by boceprevir + PEG + RBV (WBD) for 32 weeks, then:

36-week regimen: Subjects who have undetectable HCV-RNA at Treatment Week 8 discontinue treatment and enter 36 weeks of post treatment follow-up.
48-week regimen: Subjects who have detectable HCV-RNA at Treatment Week 8 are assigned an additional 12 weeks of therapy, followed by 24 weeks of post treatment follow-up. Placebo replaces boceprevir for the remaining 12 weeks of therapy, and this switch will occur in a blinded fashion.






Arm 3: Experimental
PEG + RBV (WBD) for 4 weeks followed by boceprevir + PEG + RBV (WBD) for 44 weeks with 24 weeks post-treatment follow-up.




http://clinicaltrials.gov/ct2/show/NCT00708500?recr=open&cond=%22Digestive+System+Diseases%22&rank=29

[Rockerforlife]

Arm 3 is what i want

[Rockerforlife]

Arny you in the Boc trail as well...i dont see why ya dont get the resuls as they becoma available...the trial is the exact same all over the world....watch your nurse.

[kitkat14]

Congratulations!!  Way to Go!!

k

[ram921]

I just started Boc trial here. First injection tonight.  I'm stage one level one. VL 700K. 47 years old. Work every day, etc. I plan on dropping info here regularly. I have a half dozen friends/ acquaintances who did SOC and are cleared of the virus here. EVERYONES side effects are different from each others'. There's just no predicting at all. Pisses me off major, as it flies directly in the face of all my deep-seated control issues.

[Rockerforlife]

You have very low liver damage and a very low VL...you know you have time to wait?....but i guess you have made your mind up...its a tough call...lots of people would not treat with stage one....BUT...i would go for it myself...best to fight while the liver is in fighting mode i say

[Isobella]

Great results, Rocker!!!  So glad to hear this good news.  


Ram-I'm with you--stage 1 grade 0, vl 900,000 46 years old....I knew I wasn't ever gonna be this young and healthy again, lol.  I'm in week 21 of a Vertex trial....haven't looked back.  Light sides too.....can't ask for more----except SVR

Good luck to you both =)

Isobella

[Fl_Gator]

I'm in a Telaprevir trial...no VL info for me...not till they release the results of the study.

I am excited for you...your news is good so far...hope mine will be also.

[Rockerforlife]

You both have minium sides?...im depending on the BOC....if not...i will have to do 72 weeks of SOC later....thougts ill keep away for now....it XMAS TIME FOR GODS SAKE

[virgocharm]

big congrats rock.wow thats good news. i think its done. you kicked as----.

[Isobella]

Yeah, I would say I am having minimal sides.  Triple therapy was the worst of it--but still, I feel the sx were easy on me even them.  Mostly involved scratching places that were hard to reach while I was driving, lol!

And believe me....I am watching you very closely in this trial.  I'm just the first in my family that will be tx'ing.......I want to be very familiar with all options.

So, please keep me (us all) posted....good, bad and ugly....I need to hear it all.  =)

And I want to thank you for being in this trial.  I know as patients we receive benefits from it, and the pharmas receive benefits from it.  But to me it is most important that future heppers benefit.......d@mn, these drugs have me emo today, lol!!!

Keep kickin the dragon, Rocker!!!

Izzy

[Rockerforlife]

it aint over till the skinny toothpick lady breaks wind.

[Rockerforlife]

i meant fat lady singing...my humor can be a wee bit strange

[Rockerforlife]

good...bad ugly?....you just described me

[Isobella]

Your humor can be a wee bit strange......um, hadn't noticed as I'm usually too busy laughing along, lol!!

good, bad, and the ugly....actually describes me and my sisters....but that's another story

[Marcia2202]

yes... the word good is supposed to be replaced with  good, kind, beautiful and precious... and that is you my sweet sis'