G 3a

[Marcia2202]

Hi all fellow 3a's,

I just wanted to get a little over sight on who is/was G 3a and if you would care to shortly share your experiences in txing.

I am G 3a, VL 2.2 million, dx March 08, infected ca 25 years

Biopsy : scheduled July 30

Should start tx mid August

Marcia

[meki]

Me...

3a - DX 2006 - TX 2006/2007 - SVR 2008

I'm quick and easy... LOL!

[comeagain]

Dont know which subtype i am (just that I am a geno3) neither do anyone they havent been checking for that,
is it important to know that?
My base line vl was 3.3milj iuml 6.58 log
It can vary a half log up and down and that is quit much.

Now to the interesting part, my biopsy and this i will tell you before you do yours.
You are not alowed to eat or drink any thing before a certain time before the bx, make sure you eat as near that timelimit as possible because when you eat the bile (gall) will empety it selfs and get smaller so it will make the chanses of hitting that by misstake much lesser.

Now back to my bx story i did one 2005 that was a fiasko although they used ultrasound.
The only one that worked i did nov 2007 after my first tx and 1and a half month before my present tx.

I have had the virus probebly since 1972-1973 Ive got HBV then due to iv use my doc said i most likely got the c at the same time.

Anyway i was diagnosed 16 years ago non a non b it was called.
last time i was exposing my self to any risk was januar 1987 so thats the minimum time.

Before my bx my doc said he could almust warrant that I was stage 3 .
So it was very surprising when I´ve got the result inflamation (inflammation) grade 1 stage 0.

To be honest i dont really trust that result because of my sever problems for many many years fatigue , joint pain, lower backpain, general stiffnes. burning sensations in legs and feets, insomnia moodswings and probebly more things i just can´t think of right now.

my platelets aint very high they were 200 before first tx and even a little lower before this one  my anc are also in the lower ranch of normal when not on tx, so i think i´m gonna post the question whether i can trust that bx result or not to dr D.

I think you know my tx story a brief summary <15 but detectebul at week 4 vl result so called borderline result  probebly that 12 little buggers dissapered the very same evening when i took shot 5, why do I believe that? because I´ve been UND before at week 12 maybe earlier and at EOT at my first tx.
They didn´t do any vl tests on geno 2 and 3 beforeweek 12 back then and it is only 1and a half year before I´ve started this one in 10 of januar 2008.

So you can consider your self lucky!
I´m the first born child that the parents needed to pratice on and do all the misstakes on.
your a younger sister they wont do the same to you hopefully.

Whats talks to my favor this time compared with first time is extended tx time double
48w  and much higher riba 1200mg instead of 1000 and I´m 9kg lighter, the interferon was probebly also to little first time only got 100mcl last time now its another brand and another sort of pegulated inteferon pegasys always 180mcl for everyone cant compare them, but i´ve got a feeling I´m getting more of that this time aswell.

And you know i belive in the wart theory if Bill 1954 dont clear I wont anymore.
Hope this can help you or some other geno3s

M  the g G b and p y

ca

[desrt]

Wellll, my genotype report loooked like 3e, but it was sorta smudged - it mighta been an 'a'.
Richard Sallie's "Replicative Homeostasis III" lists all 3s as having 9063 nucleotides, so I guess we're a lot more closely related than1s who vary from 9030 to 9042.
I e-mailed him for some clarifications, so maybe he'll respond. He hasn't posted here in a while.

[Marcia2202]

Thank you for your long informative post.

biopsy: I'm going in the 29th for pre biopsy blood work and then they will give me all the instruction of fasting 8 hrs prior etc. I will come back the next morning for the biopsy.

I am cutting all blood thinning supplements and foods like too chili, fish oil, to much garlic etc. Am not taking any meds or supplements at all until at least 1 week after the biopsy. That will probably coincide with the time I start tx.

I'm the youngest child, but it seems that my life has been as much as an 'experiment' as my eldest sister....But my life has smoothened out so much during the last 10 years, that I hope tx will not follow the 'old pattern', but it will follow the 'new pattern'.  need to leave it up to God. All we can do is use what he has given us, to inform and prepare ourselves, and the rest we have to give up for him to do what he pleases.

Thanks again, my friend.

Marcia

[Marcia2202]

Interesting. I will check up on that one. Can you tell me where to find this study.

Thanks, marcia

[nerja2007]

I am 3b, I Ireland they only do byopsy on g 1 nowadays. It is a new thing. I was detected in 2000, but might had had it since I was born.... Tx started April 2008, now on 16th week, very itchy (as you know), but thanks to all you kind people here found some relief following advices and am fighting through it with goods people's support- Marcia, you are one of them. LOL
Nerja

[bennett_st]

Hi

From another 3a.  Since 84.  Told 94.  Saw specialist once in 1999 who told me type and low viral load. Get LFTs every year which are normal.  Due again in October.  Like to think I have a mild case of this disease but am thinking about talking biopsy when I see the doc in October and then who knows...........

[bennett_st]

P.S.

Good luck with your biopsy.  

[desrt]

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17355620

[nygirl7]

kalio was a g3a I believe - she treated and relapsed and then treated again with HRs help and got SVR!  :)  Finally whoooo hooooo!

[desrt]

Reply to some questions re: geno3/geno3e by R. Sallie

"Genotype 3 is completely sequenced (as are most of the others); the work has mostly been done by people like Peter Simmonds in the UK and the NIH groups (where I was once).  All genotype 3s, as far as I am aware, have 9063 nucleotides.  There are consensus 3e sequences published and apart from some minor variations (for example, in the non-codiing 3' end) they are the same the world over.  The sequences of all genotypes are defied by sequences in a variety of areas , including the 5'UTR, the polymerase gene sequences and the H7 protein and envelope sequences (hence the replicative homeostasis concept).
I hope this helps,
Cheers,
sallier"

[Marcia2202]

Thanks nerja. In Dk they generally don't do biopsies on 2s and 3s anymore either. But I asked my docs to do it and they agreed. I hope your itching is gonna go soon. Good luck.

Marcia

[Marcia2202]

Thanks. I see you are taking the wait and watch approach. I hope your biopsy will show no or minimal damage.

Marcia

[Marcia2202]

Thanks for letting me know about Kalio. I hope she'll chime in some time.

marcia

[Marcia2202]

Wow, that was some really brainy stuff. Really interesting. I must admit that i couldn't read the whole thing at once. Kind of skipped the irrelevant stuff in between. My little brain can't room that much info. :-)

Marcia

[desrt]

http://www.virologyj.com/content/5/1/78

July 9 2008 Virology Journal abstract of paper studying 3a with link to full report.

[gauf]

Yup, 3a here.