Aa
Viral loads
I've just got results back from a 'Roche COBAS Ampliprep/Taqman HCV' test.
Reading other viral load questions folk are talking in 1000's, 10,000's and millions.
After 21 years, if the 2.62E+5 IU/mL result really does translate into a viral load of almost 3 then I'll buy a Lotto ticket. I feel rough so I'm hoping you good folks speak 'Blond.'
What do IU & mL represent? Is it Intravenous Units and micro Liters?
Where does the E come into it?
An explanation would be terrific.
Thanks.
Reading other viral load questions folk are talking in 1000's, 10,000's and millions.
After 21 years, if the 2.62E+5 IU/mL result really does translate into a viral load of almost 3 then I'll buy a Lotto ticket. I feel rough so I'm hoping you good folks speak 'Blond.'
What do IU & mL represent? Is it Intravenous Units and micro Liters?
Where does the E come into it?
An explanation would be terrific.
Thanks.
LOL!
Well, as I understand it different tests translate as different number of copies to 1 IU/ml. Don't ask me why. I also figure one actual copy ought to be equal to another actual copy whatever test you use. Apparently not.
"Converting copies per milliliter to International Units
There is no standard conversion formula for converting the
amount of HCV RNA reported in copies per milliliter to the
amount reported in International Units. The conversion factor
ranges from about one to about five HCV RNA copies per
IU. Usually the lab report will list the conversion from IU/mL to
copies/mL. See Table 1 for a conversion of common viral load
tests from IUs to copies.
Table 1: Common viral load measurements converted
from International Units to copies/mL.
Assay Conversion Factor
Amplicor HCV Monitor v2.0
(manual procedure) ........................1 IU/mL = 0.9 copies/mL
Cobas Amplicor HCV Monitor v2.0
(semi-automated procedure)............1 IU/mL = 2.7 copies/mL
Versant HCV RNA 3.0
Quantitative Assay...........................1 IU/mL = 5.2 copies/mL
Cx HCV RNA
Quantitative Assay...........................1 IU/mL = 3.8 copies/mL
SuperQuant....................................1 IU/mL = 3.4 copies/mL"
http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Viralload_%202007.pdf
Well, as I understand it different tests translate as different number of copies to 1 IU/ml. Don't ask me why. I also figure one actual copy ought to be equal to another actual copy whatever test you use. Apparently not.
"Converting copies per milliliter to International Units
There is no standard conversion formula for converting the
amount of HCV RNA reported in copies per milliliter to the
amount reported in International Units. The conversion factor
ranges from about one to about five HCV RNA copies per
IU. Usually the lab report will list the conversion from IU/mL to
copies/mL. See Table 1 for a conversion of common viral load
tests from IUs to copies.
Table 1: Common viral load measurements converted
from International Units to copies/mL.
Assay Conversion Factor
Amplicor HCV Monitor v2.0
(manual procedure) ........................1 IU/mL = 0.9 copies/mL
Cobas Amplicor HCV Monitor v2.0
(semi-automated procedure)............1 IU/mL = 2.7 copies/mL
Versant HCV RNA 3.0
Quantitative Assay...........................1 IU/mL = 5.2 copies/mL
Cx HCV RNA
Quantitative Assay...........................1 IU/mL = 3.8 copies/mL
SuperQuant....................................1 IU/mL = 3.4 copies/mL"
http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Viralload_%202007.pdf
To: Wassup. Sev will do just fine. The Japanese managed to isolate Hep C outside the body by putting it in a mouse and have had some success curing said mouse and are further testing a vaccine. I thought I'd eat it. (Cat like grin) but ransome now there's a whole new kettle of mice.
I'm in the process of selling my house to fund luxurious trips to act as lab rat so best I scram.
Ciao for now.
I'm in the process of selling my house to fund luxurious trips to act as lab rat so best I scram.
Ciao for now.
Zazza - The key word here is international. By using International Units test results all over the world can be compared with each other.
What the rest of the world cant count in 1s.
CS
What the rest of the world cant count in 1s.
CS
Please don't report me to MedHelp, I was just playing with MY MOUSE!!!! Hee Hee, Hee Hee.
I don't think "sever" is a good nickname for you so I'll call you 'Sev.', OK? I just had to ask about the japanese mouse, (was he carrying chopsticks or wearing a tiny little kimona)? How can you tell he's Japanese, AND What will you do with him, pray tell, once you've kidnapped him? Will you send a tiny ransome note, "Kinichiwah, (most likely misspelled), if you don't stay out of my kitchen, I'm gunna execute your little friend". ("AND IT WON'T BE PRETTY"). WERE YOU THINKING OF EATING THE MOUSE? I'm SOOOO CONFUSED.
So, I obviously don't think you're crazy. Takes one to know one. I've gotta love your automotive analogies. She said "anal', hee hee, hee hee! My neice has an allergy to Gluten. They thought it was Candida, the rash was horrible, and itched so badly it nearly drove her nuts.
Thank you, in advance, Sev., for answering my many queries. She said 'queer'hee hee, hee hee. < THAT WAS MY BEST bEVIS & bUTTHEAD impression, (stupid caps lock). Best of luck on your journey, Sending a hug along with all the sillyness, Ant B
So, I obviously don't think you're crazy. Takes one to know one. I've gotta love your automotive analogies. She said "anal', hee hee, hee hee! My neice has an allergy to Gluten. They thought it was Candida, the rash was horrible, and itched so badly it nearly drove her nuts.
Thank you, in advance, Sev., for answering my many queries. She said 'queer'hee hee, hee hee. < THAT WAS MY BEST bEVIS & bUTTHEAD impression, (stupid caps lock). Best of luck on your journey, Sending a hug along with all the sillyness, Ant B
Peachy keen. Thanks so much everyone for the warm welcome. I'll follow up on that link and take some time finding my way around.
'CockSparrow' Excellent thank you. My GP had no idea but he's good enough to say so.
262,000 IU/mL I may just buy that Lotto ticket anyway. (Grins)
It's weird though, how so often the lab results don't reflect how you actually feel.
I'll find myself speeding down the Low Immunity Highway, Muscle Fatigue shoots a piston at the start line, putting me neck and neck with Bronchitis and Pleurisy, having dragged off several versions of the Flu. Abdominal pain wipes out through the bends and just as I accelerate thinking I'm getting somewhere.. my front tyre hits a rose prickle and Toxic Shock wins the day.
Yet according to every test known to man, heh. I'm an Olympian.
'I'm not crazy really I'm not'. I tested positive in 1992, back then there was an 8% success rate, with an Interferon only menu. 42 side effects and no idea how long term the success might be.
A tattoo for my sweet 15th, not my best idea. Things have certainly changed now, not so much in Kiwi land but off shore there are now treatments in the works with much higher success rates.
I've looked at other support forums, they seemed to be just that. Until now. Being a member will make keeping up with current research easier and I firmly believe that it's the people who battle the dragon that have the most information. They're printing as fact now, what we worked out years back. Thanks again for the friendly replies, and saving me from hours of trawling the net. I can go back to plotting the kidnapping of a certain Japanese mouse.
Mouse on gluten free crackers...Yummy.
'CockSparrow' Excellent thank you. My GP had no idea but he's good enough to say so.
262,000 IU/mL I may just buy that Lotto ticket anyway. (Grins)
It's weird though, how so often the lab results don't reflect how you actually feel.
I'll find myself speeding down the Low Immunity Highway, Muscle Fatigue shoots a piston at the start line, putting me neck and neck with Bronchitis and Pleurisy, having dragged off several versions of the Flu. Abdominal pain wipes out through the bends and just as I accelerate thinking I'm getting somewhere.. my front tyre hits a rose prickle and Toxic Shock wins the day.
Yet according to every test known to man, heh. I'm an Olympian.
'I'm not crazy really I'm not'. I tested positive in 1992, back then there was an 8% success rate, with an Interferon only menu. 42 side effects and no idea how long term the success might be.
A tattoo for my sweet 15th, not my best idea. Things have certainly changed now, not so much in Kiwi land but off shore there are now treatments in the works with much higher success rates.
I've looked at other support forums, they seemed to be just that. Until now. Being a member will make keeping up with current research easier and I firmly believe that it's the people who battle the dragon that have the most information. They're printing as fact now, what we worked out years back. Thanks again for the friendly replies, and saving me from hours of trawling the net. I can go back to plotting the kidnapping of a certain Japanese mouse.
Mouse on gluten free crackers...Yummy.
"IU= International Units is apx 2.5 actual virual copies.
No Idea what the hell was wrong with copies but hey I dont do research."
The key word here is international. By using International Units test results all over the world can be compared with each other.
You beat me on that "E" though. Did not know what that meant.
No Idea what the hell was wrong with copies but hey I dont do research."
The key word here is international. By using International Units test results all over the world can be compared with each other.
You beat me on that "E" though. Did not know what that meant.
Quote - if the 2.62E+5 IU/mL result really does translate into a viral load of almost 3 then I'll buy a Lotto ticket
You are going to have to hold off on buying that lotto ticket, but only just.
Your VL is in scientific notation. "E" represents "times ten raised to the power",
"2.62 E+5" so E+5 = 10 to the power of 5 which is 100000.
in other words add 5 zeros to the right of a 1.
So 2.62 X 100,000 = 262,000 IU/mL
IU= International Units is apx 2.5 actual virual copies.
No Idea what the hell was wrong with copies but hey I dont do research.
mL= MilliLiter or 1000th of a liter.
What all this means is your VL is quite low and you stand an exellent chance of SVR. So long as you respond to the drugs that is.
All the Best
CS
You are going to have to hold off on buying that lotto ticket, but only just.
Your VL is in scientific notation. "E" represents "times ten raised to the power",
"2.62 E+5" so E+5 = 10 to the power of 5 which is 100000.
in other words add 5 zeros to the right of a 1.
So 2.62 X 100,000 = 262,000 IU/mL
IU= International Units is apx 2.5 actual virual copies.
No Idea what the hell was wrong with copies but hey I dont do research.
mL= MilliLiter or 1000th of a liter.
What all this means is your VL is quite low and you stand an exellent chance of SVR. So long as you respond to the drugs that is.
All the Best
CS
Hey There Sev.., If you click on health pages link at the top of this page, you'll find acronym lists, and a lot of stuff to help you understand all this 'hepper' (nick name for folks with Hepatitus), jargon. Don't ever be bashful about asking any question at all. There'll always be someone here to come to the rescue, with an answer, or at least a place to find one. Welcome, Hug, Ant B
Have an Answer?
You are reading content posted in the Hepatitis Social Community
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
