Hi.
Cold agglutinins are antibodies that cause the red blood cells to clump or aggregate when the blood temperature falls below the normal body temperature. There are a variety of conditions with cold agglutinins present, including mononucleosis, mumps, measles, and hemolytic anemia.
The spleen traps most of the abnormal red blood cells circulating in the body. This causes the spleen to enlarge. Splenectomy or surgical removal of the spleen can be done as treatment, depending on the cause. But splenectomy is not commonly done especially when there are other forms of treatment available specific for the cause. Post-splenectomy patients are more prone to develop infections from any opportunistic organisms.
Just saw a case of lymphoma which was isolated in the spleen & they were able to remove the man's spleen which was the size of a football. He also was suffering from something called cold agglutinins which was cured by the removal of the spleen and no chemo or Rads were administered. I saw this on Mystery Diagnosis. Do you know anything about cold agglutinins because most of the Doctors he went to didn't seem to have a clue about it.
Hi.
Lymphoma can develop as a result of changes in the genes, involving chromosomal translocations, additions or deletions. Exposures to a variety of agents like infectious agents, environmental and occupational exposures, or even diet can cause lymphoma.
Signs and symptoms of lymphoma include fever, unexplained weight loss, night sweats, itchiness of the skin, appearance or enlargement of lymph nodes, and splenomegaly (enlargement of spleen).
Laboratory examinations helpful in the diagnosis of lymphoma are complete blood count with differential count, blood chemistry including lactic dehydrogenase. Imaging studies like chest x-ray, CT scan, and magnetic resonance imaging are also helpful. A definite diagnosis can be derived from a tissue biopsy.
In general, lymphomas are treatable. Chemotherapy and radiation therapy are among the mainstays in the management of lymphomas.