Someone please

[Lovemykids45622]

My 8 year old has had 24 colds in 13 months. We started seeing an immunologist because I have thought he is immune compromised.
His blood in May was pretty normal except for a high wbc which it was done about 6 days after a minimal operation.
Fast forward to October.
WBC and rbc in range but both on low end. Neutrophils are only 36 and lymphs 55. Absolute lymphs were 4.1.  Ok so doc offered more bw.  

Got new panels. WBC. Within range but low end. Very low. Rbc within range but on the low end.

Neutrophils 35
Lymphs 54
Monocytes 9
Cd 8 pos lymphs 17.3 low.

He has had chronic colds that come
With a fever that can last a while and then return. As soon as he is on the mend he gets knocked back down again. And now again he is sick. He has been pulled from school due to the excessive illnesses in September alone. He had had swollen nodes in his neck for a while. Lately he has complained about headaches and leg pain but not a lot. Also develops a
Reddish rash.

Is it time to call a hematologist? I'm starting to worry more. I am waiting for our ped to call. We got back to the immunologist on Monday. Any info is greatly appreciated.
Neutrophils are supposed to be higher then that right?

[Lovemykids45622]

Within my research thus far along with lymphoma there is something called Di George syndrome which kind of makes sense.

This is by far frustrating. He is on home instruction and will remain until these docs get this under control. Only one problem he doesn't take medication by mouth so come when they do figure it out until he can manage that I don't know what we will do.  

He has the periods of illness and they linger. I'm waiting for ped to call me  our local lab closes by 3pm today I think (I have to look)

[Ken_PA]

It's funny you say Di George because this is the first page that I looked at:
http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/digeorge-syndrome/


Has your son had a mineral panel to look for hypocalcemia? That might explain various motor problems. too. That's not an expensive test. I'd ask for that test.


There's been such a lot of hype about vitamin D in recent years, but I'd want that tested too to see if he is very low.

I also happened upon this for starters:
"It is also proposed that deprivation of sunlight and vitamin D at higher latitudes facilitates the development of autoimmune diseases by aggravating the CD8+ T-cell deficiency"
http://www.hindawi.com/journals/ad/2012/189096/

That's not a 'high impact' journal, but is good for starters.

[Lovemykids45622]

I wish there was a simple answer to all this. Hopefully I will find out soon because this is driving me batty now. And the fact that he is sick again has me baffled. He hasn't been in school

[Lovemykids45622]

Almost like he's a transplant patient who hasn't taken their immunosuppressants. Like his body is attaxking itself

[Ken_PA]

"Like his body is attaxking itself"

Autoimmunity – Patients with DGS develop autoimmune disease at a rate that is higher than in the general population. Autoimmune disease occurs when the immune system inappropriately attacks its own body. (See chapter titled “Autoimmunity in Primary Immunodeficiency.”) It is not known why this happens in people with T-lymphocyte problems. The most common autoimmune diseases in DGS are idiopathic thrombocytopenia purpura (antibodies against platelets), autoimmune hemolytic anemia (antibodies against red blood cells), autoimmune arthritis, and autoimmune disease of the thyroid gland.


So there as mentioned previously is anemia from destruction of red blood cells. Does he ever bruise easily? That's be low platelets.

[Ken_PA]

"Almost like he's a transplant patient who hasn't taken their immunosuppressants"


That would also apply to any transfusions. What was his surgery for?

From that same page on Di George Syndrome:
Surgery can be performed before any immune defects are corrected. If there is a problem with the T-cells, precautions must be taken as with other children with congenital T-cell immunodeficiencies. These include irradiating all blood products to prevent graft vs. host disease and ensuring the blood products are free of potentially harmful viruses.