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Help needed interpreting medical journal sentences
by bulls, Jan 27, 2009 07:27AM
I'm hoping that a doctor can help me please (unfortunately since I live in Australia by the time I go online the doctor question board is always full........ hence the post here .... )
I'm reading an article called "Paraneoplastic syndromes affecting the nervous system" and I'm having trouble understanding a few sentences.
I myself was diagnosed with paraneo. limbic encephaltis years ago now (some of which have gotten worse with time) and am left with many serious residual problems and want to find the basis of them to see if there's a diagnosis that's been missed given that it's so rare in Australia. I do have CNS damage because I suffer chronic pain that they have said is CNS damage (burning all over my body) I've read of others with my diagnosis of limbic enceph. that recover quite well.
In the article (that I was able to get from the local hospital) it says
"In other neurologic disorders, particularly those involving the CNS treatment of the cancer has little or no effect on the paraneoplastic syndromes. In some instances, even after years of remission of the underlying cancer, antineuronal antibody titers remain elevated. In most patients with CNS paraneoplastic syndromes, the neurologic symptoms do not subjstantially progress after the successful treatment of the cancer, but the meaning of this is unclear because paraneoplastic syndromes usually stabilize after several months even when the cancer is untreated"
This phrase seems to fit me because although my memory has improved significantly with the treatment (chemotherapy etc) all the other problems are still there and some are even worse. Things like horrendous fatigue, chronic hunger & thirst, taste & smell problems, constant need to urinate etc etc
I don't know what "antineuronal antibody titers remain elevated" means - I know from googling it that it's an "anitibody that reacts with nerve cells or never endings" but I don't know what this means in the sentence.
What are the side effects of the elevation?
Could it be related to the symptoms that I have mentioned above? (including the CNS pain)
If they are elevated is it possible to try treatment to reduce the levels?
Finally, what does the paragraph mean in general for someone like me?
Thanks doctors - I'd appreciate ANY help you can give me ..... anything.
---------------
In case it helps this is the abstract of the article as it appears in Pubmed
http://www.ncbi.nlm.nih.gov/pubmed/16769417
I'm reading an article called "Paraneoplastic syndromes affecting the nervous system" and I'm having trouble understanding a few sentences.
I myself was diagnosed with paraneo. limbic encephaltis years ago now (some of which have gotten worse with time) and am left with many serious residual problems and want to find the basis of them to see if there's a diagnosis that's been missed given that it's so rare in Australia. I do have CNS damage because I suffer chronic pain that they have said is CNS damage (burning all over my body) I've read of others with my diagnosis of limbic enceph. that recover quite well.
In the article (that I was able to get from the local hospital) it says
"In other neurologic disorders, particularly those involving the CNS treatment of the cancer has little or no effect on the paraneoplastic syndromes. In some instances, even after years of remission of the underlying cancer, antineuronal antibody titers remain elevated. In most patients with CNS paraneoplastic syndromes, the neurologic symptoms do not subjstantially progress after the successful treatment of the cancer, but the meaning of this is unclear because paraneoplastic syndromes usually stabilize after several months even when the cancer is untreated"
This phrase seems to fit me because although my memory has improved significantly with the treatment (chemotherapy etc) all the other problems are still there and some are even worse. Things like horrendous fatigue, chronic hunger & thirst, taste & smell problems, constant need to urinate etc etc
I don't know what "antineuronal antibody titers remain elevated" means - I know from googling it that it's an "anitibody that reacts with nerve cells or never endings" but I don't know what this means in the sentence.
What are the side effects of the elevation?
Could it be related to the symptoms that I have mentioned above? (including the CNS pain)
If they are elevated is it possible to try treatment to reduce the levels?
Finally, what does the paragraph mean in general for someone like me?
Thanks doctors - I'd appreciate ANY help you can give me ..... anything.
---------------
In case it helps this is the abstract of the article as it appears in Pubmed
http://www.ncbi.nlm.nih.gov/pubmed/16769417
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