Very high CK levels with elevated AST/ALT levels

[truelyaqt]

My husband is 29 years old and has recently had some concerning lab results. First, his ALT and AST levels were both in the 60's. He had them repeated 2 weeks later and the results were increased to the high 60's and low 70's. He also had a CK level drawn that came back as 3947. He is a pretty active guy and has been all his life, not necessarily working out, but having a very active, fast-paced job as a delivery driver with lifting involved. He is always doing things around the house too. He almost never drinks alcohol either, maybe one or two beer every month or two. When he was a young boy, he was in a coma for a few days apparently with a rare "infection on the lining of his brain" that presented after a bout of pneumonia. All through his life he has had joint pain that comes and goes but was told that it was something that was a common symptom due to the type of coma he had and that he would probably deal with it his whole life, but is not severe.  Other than that, he is symptom-free and feels healthy.
He has an older brother that has apparently had similar lab results for the past 17 years except that his CK levels have been in the 10, 000's before. He has moderate fatigue every few days or so and has some hand tremors. He has apparently been to three specialist who have not diagnosed him either.

All that being said, are there any suggestions on what we should do next? Does anyone have any ideas what the symptoms might be suggesting?

Anything would help....

[lordofhosts]

I've done some "wikipedia research" because I have similar symptoms and blood analysis. Here's the anomalous values from my blood test:
>> CK -- 1076 U/L (not as high as your bf, but x10 time reference value nevertheless)
>> folic acid -- on the low side (2.6 ug/L)
>> IgE -- 1300 kU/L
>> AST/ALT -- both ~55 U/L
>> HDL/LDL and cholesterol are elevated (could be unrelated, I always have values slightly higher both good and bad chol, but they are also higher than usual)
>> Eosinophiles are elevated (not extremely, but just enough to further confirm my hypothesis I'm presenting to my doctor tomorrow.

All other values are within reference value ranges.

My hypothesis is a Schistosoma infection (small worm parasite). It affects the liver and intestines. In one of its stages of life it also travels to the lungs, in another to the anus. It can cause the following symptoms:
- malaise
- diarrhea and/or bloody stool
- bladder dysfunction
- tiredness
- loss of appetite
- joint and muscle pains
- swollen gut
- itchiness (anus, mouth, skin where the infection occured)
- dry cough (they also pass the lungs in their cycle)

There's also a small chance that eggs might end up in sensitive areas like bone marrow and the brain, causing seizures, tremors or local paralysis. The longer it is left untreated, the more damage to the intestines, liver and possibly nervous system. All of the anomalous values from MY test seem to fit the bill. (spiked IgE is an allergic reaction to parasitic infection, with very high CK values and histamines as a consequence, low folic acid might be because liver dysfunction "bleeds" into the small intestine, where folic acid is normally absorbed. High AST and ALT values could also be attributed to liver damage caused by the parasite, as that is where they mostly migrate to and remain for a big part of their reproductive cycle. Eosinophiles are white blood cells and are used to combat parasitic/multicellular infection. I would digest this information, see if it fits the blood test of your husband and present this information to your local physican. See if he can do further testing. Don't postpone. Intestinal scarring from this infection cannot be restored. If it is this parasite, it also lays plenty of eggs each day. Hope I helped anyone.

[RoseanneSofia]

We have a very similiar situation how can we correspond how has it progressed my husband had west nile encephalitis now diagnosed with early onset Alzheimer’s at 52 please reach out to me at ***@****

[DrKalraMD]

Hi, “Elevation of CK is an indication of damage to muscle. It is therefore indicative of injury, rhabdomyolysis, myocardial infarction, muscular dystrophy, myositis, myocarditis, malignant hyperthermia and neuroleptic malignant syndrome. It is also seen in McLeod syndrome and hypothyroidism. The use of statin medications, which are commonly used to decrease serum cholesterol levels, may be associated with elevation of the CPK level in about 1% of the patients taking these medications, and with actual muscle damage in a much smaller proportion”.

For more information visit http://findarticles.com/p/articles/mi_qa4100/is_200511/ai_n15847048